FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497175404> ?p ?o ?g. }

• W1497175404 abstract "Chronic neuropathic pain is a huge public health problem that compromises the quality of life of millions of individuals. There are many causes for chronic neuropathic pain, one of them being peripheral nerve injury occurring during surgery or trauma. Even when considering only those cases resulting from surgery about 2-10% of patients undergoing various surgeries (amputation, breast surgery, thoracotomy, inguinal hernia, coronary artery bypass surgery, caesarean section) develop chronic severe (disabling) pain (Kehlet et al., 2006). In the USA alone, there are approximately 80 million surgeries performed each year (Apfelbaum et al., 2003); if only 5% of those patients went on to develop severe chronic pain, ~4 million people would be added to the list of chronic pain patients each year. Of the patients attending chronic pain clinics, 20% have implicated surgery as one of the causes of their chronic pain and, in about half of these, it was the sole cause (Macrae, 2001). The intensity of acute postoperative pain is a good predictor of long-term pain; however, adequate control of acute postoperative pain does not always lead to a decrease in the incidence of developing long term pain (Perkins and Kehlet, 2000). To reduce the level of tissue injury during surgery, surgical procedures have been modified including those used for joint repair (Kehlet et al., 2006); mastectomy and breast reconstruction (Gahm et al.; 2010; Vadivelu et al., 2008) and herniorraphy (Nathan and Pappas, 2003; Pokorny et al., 2008); however, a significant percentage of patients still develop chronic pain. Hence, there is a need to develop treatments that can be used before and during the early phases following nerve injury (as a result of surgery or trauma) to prevent the development of chronic pain. The development of chronic pain following surgery correlates with the presence of peripheral nerve injury (Macrae, 2001). Studies using various peripheral nerve injury models have shown that these models share some, but not all, of the injury-induced molecular changes that may be contributing to chronic neuropathic pain (Berger et al., 2011; Xu and Yaksh, 2011). Moreover, whether changes in a given molecule contribute to" @default.
• W1497175404 created "2016-06-24" @default.
• W1497175404 creator A5019452923 @default.
• W1497175404 creator A5066786149 @default.
• W1497175404 creator A5086048972 @default.
• W1497175404 date "2012-03-28" @default.
• W1497175404 modified "2023-10-16" @default.
• W1497175404 title "An Approach to Identify Nerve Injury-Evoked Changes that Contribute to the Development or Protect Against the Development of Sustained Neuropathic Pain" @default.
• W1497175404 cites W1481443370 @default.
• W1497175404 cites W1502160133 @default.
• W1497175404 cites W1546440097 @default.
• W1497175404 cites W1558194885 @default.
• W1497175404 cites W1588482966 @default.
• W1497175404 cites W1589594364 @default.
• W1497175404 cites W1794352460 @default.
• W1497175404 cites W1858482902 @default.
• W1497175404 cites W1931423687 @default.
• W1497175404 cites W1966568440 @default.
• W1497175404 cites W1967441802 @default.
• W1497175404 cites W1969208467 @default.
• W1497175404 cites W1969414939 @default.
• W1497175404 cites W1972907659 @default.
• W1497175404 cites W1974300877 @default.
• W1497175404 cites W1975250711 @default.
• W1497175404 cites W1975688256 @default.
• W1497175404 cites W1981002701 @default.
• W1497175404 cites W1982190221 @default.
• W1497175404 cites W1982942262 @default.
• W1497175404 cites W1986443137 @default.
• W1497175404 cites W1989112484 @default.
• W1497175404 cites W1989562312 @default.
• W1497175404 cites W1990360679 @default.
• W1497175404 cites W1992047131 @default.
• W1497175404 cites W1993346141 @default.
• W1497175404 cites W1995788686 @default.
• W1497175404 cites W1996951072 @default.
• W1497175404 cites W1998842001 @default.
• W1497175404 cites W2000178071 @default.
• W1497175404 cites W2002692790 @default.
• W1497175404 cites W2004211940 @default.
• W1497175404 cites W2011886791 @default.
• W1497175404 cites W2012564860 @default.
• W1497175404 cites W2015320412 @default.
• W1497175404 cites W2015470781 @default.
• W1497175404 cites W2018145442 @default.
• W1497175404 cites W2018579572 @default.
• W1497175404 cites W2024182346 @default.
• W1497175404 cites W2027584400 @default.
• W1497175404 cites W2036743808 @default.
• W1497175404 cites W2036758155 @default.
• W1497175404 cites W2042707882 @default.
• W1497175404 cites W2043077898 @default.
• W1497175404 cites W2043772697 @default.
• W1497175404 cites W2046902346 @default.
• W1497175404 cites W2047010161 @default.
• W1497175404 cites W2048918674 @default.
• W1497175404 cites W2052162469 @default.
• W1497175404 cites W2052309611 @default.
• W1497175404 cites W2052368774 @default.
• W1497175404 cites W2056565769 @default.
• W1497175404 cites W2056677259 @default.
• W1497175404 cites W2061236563 @default.
• W1497175404 cites W2063374838 @default.
• W1497175404 cites W2064199629 @default.
• W1497175404 cites W2064528811 @default.
• W1497175404 cites W2074391190 @default.
• W1497175404 cites W2077885131 @default.
• W1497175404 cites W2079587568 @default.
• W1497175404 cites W2081533056 @default.
• W1497175404 cites W2082309778 @default.
• W1497175404 cites W2084167190 @default.
• W1497175404 cites W2086046914 @default.
• W1497175404 cites W2086869271 @default.
• W1497175404 cites W2087152795 @default.
• W1497175404 cites W2088062536 @default.
• W1497175404 cites W2088082488 @default.
• W1497175404 cites W2088947221 @default.
• W1497175404 cites W2089435383 @default.
• W1497175404 cites W2091015977 @default.
• W1497175404 cites W2093705470 @default.
• W1497175404 cites W2098605131 @default.
• W1497175404 cites W2104400774 @default.
• W1497175404 cites W2107595042 @default.
• W1497175404 cites W2111964682 @default.
• W1497175404 cites W2113138572 @default.
• W1497175404 cites W2114725885 @default.
• W1497175404 cites W2115819911 @default.
• W1497175404 cites W2124371835 @default.
• W1497175404 cites W2126575561 @default.
• W1497175404 cites W2130141996 @default.
• W1497175404 cites W2130223176 @default.
• W1497175404 cites W2130496291 @default.
• W1497175404 cites W2133093960 @default.
• W1497175404 cites W2133347503 @default.
• W1497175404 cites W2137085579 @default.
• W1497175404 cites W2138809708 @default.
• W1497175404 cites W2139434496 @default.
• W1497175404 cites W2140441724 @default.
• W1497175404 cites W2145739946 @default.
• W1497175404 cites W2153521635 @default.

• next