FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497175510> ?p ?o ?g. }

• W1497175510 abstract "Major depressive disorder (MDD) is a serious health problem and will be the second leading cause of burden of disease worldwide by 2030. To be able to prevent MDD, insight into risk factors for the onset of MDD is of clear importance. On the other hand, if onset of MDD has occurred, one may argue that different course patterns of MDD can be identified and that it is essential to examine their relationship to symptoms and function over time. Insight into these course patterns could assist in preventive strategies and management of MDD. The first aim of this thesis was to examine the differential impact of risk factors for the onset of MDD across groups at risk and to investigate to what extent our findings accord with the vulnerability-stress model for MDD. The second aim was to examine the natural course and outcome of MDD. The first main topic of this thesis includes the influence of risk factors on the onset of MDD. The first noteworthy finding is that several risk factors can be identified that may help to predict onset of different types of MDE. These factors are relatively easily assessable and may assist in preventive strategies. The second noteworthy finding is that the majority of risk factors had a greater impact in women than in men on the risk of onset of MDD and were not restricted to a specific class of risk factors. These findings may partly account for the observed difference in incidence of MDD between men and women. Third, recent life events carry the largest risk of onset of MDD in mid-life. Understanding the different vulnerability to life events according to age may help to indicate groups at a particular risk and assist in preventive strategies. In the present thesis we showed that several vulnerability factors and stress factors not only work in an additive way but also interact, which accords with the interactive vulnerability variant of the vulnerability-stress model. The second main topic comprises the course and outcome of MDD. The first noteworthy finding is that we found that the majority of patients diagnosed with MDD have a chronic or intermittent course. Chronic courses are associated with higher levels of depressive symptoms and somatic symptoms and greater mental dysfunction at baseline. The second noteworthy finding is that depression and anxiety together or alone had a lower level of physical function at baseline than those with no diagnosis. Physical function may increase over time, but the rate of increase may not be different between the diagnostic groups. On the other hand, lower levels of physical function may lead to onset of depression and anxiety over time. Therefore, it is essential to prevent lower levels of physical function, and to prevent onset of both depression and anxiety. The third noteworthy finding is that a minority of patients with MDD is recognised in primary care. Those who are unrecognised have comparable outcome after 12 and 39 months as participants with recognised depression." @default.
• W1497175510 created "2016-06-24" @default.
• W1497175510 creator A5021674634 @default.
• W1497175510 date "2011-06-08" @default.
• W1497175510 modified "2023-09-24" @default.
• W1497175510 title "Epidemiology of major depressive disorder" @default.
• W1497175510 cites W1488078419 @default.
• W1497175510 cites W1573984888 @default.
• W1497175510 cites W1776741287 @default.
• W1497175510 cites W1874698854 @default.
• W1497175510 cites W1881281756 @default.
• W1497175510 cites W1893157806 @default.
• W1497175510 cites W1966111962 @default.
• W1497175510 cites W1973806188 @default.
• W1497175510 cites W1983771555 @default.
• W1497175510 cites W1989126018 @default.
• W1497175510 cites W1990663212 @default.
• W1497175510 cites W1999675919 @default.
• W1497175510 cites W2002082408 @default.
• W1497175510 cites W2011792474 @default.
• W1497175510 cites W2017187690 @default.
• W1497175510 cites W2017930909 @default.
• W1497175510 cites W2032149427 @default.
• W1497175510 cites W2041826937 @default.
• W1497175510 cites W2055218553 @default.
• W1497175510 cites W2064461442 @default.
• W1497175510 cites W2076126919 @default.
• W1497175510 cites W2078057308 @default.
• W1497175510 cites W2089797301 @default.
• W1497175510 cites W2098547359 @default.
• W1497175510 cites W2099610924 @default.
• W1497175510 cites W2099676946 @default.
• W1497175510 cites W2105387850 @default.
• W1497175510 cites W2106349848 @default.
• W1497175510 cites W2106494108 @default.
• W1497175510 cites W2108312407 @default.
• W1497175510 cites W2110608362 @default.
• W1497175510 cites W2118304798 @default.
• W1497175510 cites W2118532778 @default.
• W1497175510 cites W2120199780 @default.
• W1497175510 cites W2125056793 @default.
• W1497175510 cites W2126253977 @default.
• W1497175510 cites W2127715601 @default.
• W1497175510 cites W2135691777 @default.
• W1497175510 cites W2144626458 @default.
• W1497175510 cites W2144878901 @default.
• W1497175510 cites W2147182129 @default.
• W1497175510 cites W2147750989 @default.
• W1497175510 cites W2156104108 @default.
• W1497175510 cites W2159061031 @default.
• W1497175510 cites W2160096424 @default.
• W1497175510 cites W2243127645 @default.
• W1497175510 cites W2413281882 @default.
• W1497175510 cites W2797597138 @default.
• W1497175510 hasPublicationYear "2011" @default.
• W1497175510 type Work @default.
• W1497175510 sameAs 1497175510 @default.
• W1497175510 citedByCount "11" @default.
• W1497175510 countsByYear W14971755102012 @default.
• W1497175510 countsByYear W14971755102013 @default.
• W1497175510 countsByYear W14971755102014 @default.
• W1497175510 countsByYear W14971755102015 @default.
• W1497175510 countsByYear W14971755102017 @default.
• W1497175510 countsByYear W14971755102019 @default.
• W1497175510 crossrefType "dissertation" @default.
• W1497175510 hasAuthorship W1497175510A5021674634 @default.
• W1497175510 hasConcept C107130276 @default.
• W1497175510 hasConcept C118552586 @default.
• W1497175510 hasConcept C126322002 @default.
• W1497175510 hasConcept C139719470 @default.
• W1497175510 hasConcept C15744967 @default.
• W1497175510 hasConcept C162324750 @default.
• W1497175510 hasConcept C2776867660 @default.
• W1497175510 hasConcept C2780051608 @default.
• W1497175510 hasConcept C2780733359 @default.
• W1497175510 hasConcept C38652104 @default.
• W1497175510 hasConcept C41008148 @default.
• W1497175510 hasConcept C70410870 @default.
• W1497175510 hasConcept C71924100 @default.
• W1497175510 hasConcept C95713431 @default.
• W1497175510 hasConceptScore W1497175510C107130276 @default.
• W1497175510 hasConceptScore W1497175510C118552586 @default.
• W1497175510 hasConceptScore W1497175510C126322002 @default.
• W1497175510 hasConceptScore W1497175510C139719470 @default.
• W1497175510 hasConceptScore W1497175510C15744967 @default.
• W1497175510 hasConceptScore W1497175510C162324750 @default.
• W1497175510 hasConceptScore W1497175510C2776867660 @default.
• W1497175510 hasConceptScore W1497175510C2780051608 @default.
• W1497175510 hasConceptScore W1497175510C2780733359 @default.
• W1497175510 hasConceptScore W1497175510C38652104 @default.
• W1497175510 hasConceptScore W1497175510C41008148 @default.
• W1497175510 hasConceptScore W1497175510C70410870 @default.
• W1497175510 hasConceptScore W1497175510C71924100 @default.
• W1497175510 hasConceptScore W1497175510C95713431 @default.
• W1497175510 hasLocation W14971755101 @default.
• W1497175510 hasOpenAccess W1497175510 @default.
• W1497175510 hasPrimaryLocation W14971755101 @default.
• W1497175510 hasRelatedWork W14119511 @default.
• W1497175510 hasRelatedWork W1598850072 @default.
• W1497175510 hasRelatedWork W1986348607 @default.

• next