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- W1497180129 endingPage "32" @default.
- W1497180129 startingPage "15" @default.
- W1497180129 abstract "Almost half a century ago, researchers demonstrated that the ratio of stable carbon isotopes in exhaled breath of rats and humans could reveal the oxidation of labeled substrates in vivo, opening a new chapter in the study of fuel use, the fate of ingested substrates, and aerobic metabolism. Until recently, the combined use of respirometry and stable-isotope tracer techniques had not been broadly employed to study fuel use in other animal groups. In this review, we summarize the history of this approach in human and animal research and define best practices that maximize its utility. We also summarize several case studies that use stable-isotope measurements of breath to explore the limits of aerobic metabolism and substrate turnover among several species and various physiological states. We highlight the importance of a comparative approach in revealing the profound effects that phylogeny, ecology, and behavior can have in shaping aerobic metabolism and energetics as well as the fundamental biological principles that underlie fuel use and metabolic function across taxa. New analytical equipment and refinement of methodology make the combined use of respirometry and stable-isotope tracer techniques simpler to perform, less costly, and more field ready than ever before." @default.
- W1497180129 created "2016-06-24" @default.
- W1497180129 creator A5016193628 @default.
- W1497180129 creator A5052091382 @default.
- W1497180129 creator A5054934033 @default.
- W1497180129 creator A5059418152 @default.
- W1497180129 creator A5082538077 @default.
- W1497180129 date "2015-03-27" @default.
- W1497180129 modified "2023-10-04" @default.
- W1497180129 title "Carbon stable-isotope tracking in breath for comparative studies of fuel use" @default.
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