Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497228230> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1497228230 endingPage "270" @default.
- W1497228230 startingPage "265" @default.
- W1497228230 abstract "The aim of this study was to compare noninvasive biomarkers, FibroTest and ActiTest in predicting fibrosis stage and inflammation grade in chronic hepatitis C (CHC) patients with liver biopsy (LB).In 107 patients with CHC, levels of six serum biomarkers (alanine aminotransferase, γ-glutamyl transpeptidase, total bilirubin, haptoglobin, apolipoprotein, α-2 macroglobulin) were determined at the time of LB. LB was evaluated by Metavir score for fibrosis and inflammation. Voluntary blood donors (n=106) were taken as controls for the study.Fibrosis estimated by Fibrotest was significantly higher in patients compared to control group. The observed area under the receiver operating characteristic curve (AUROC) for advanced fibrosis (F3, F4) adjusted according to the observed difference between advanced and non-advanced fibrosis prevalence (DANA) was 0.80 (0.69-0.88) and the AUROC for cirrhosis (F4) was 0.94 (0.86-0.98). ActiTest AUROC for moderate to severe activity (A2A3) was 0.72 (0.61-0.81), and for severe activity (A3) was 0.88 (0.78-0.93). The diagnostic values in the group of good quality biopsy (n=41) showed Fibrotest AUROC (DANA-adjusted): for advanced fibrosis 0.90 (0.72-0.99); for cirrhosis 0.93 (0.76-0.98); and ctiTest AUROC: for moderate/severe activity 0.86 (0.67-0.94); and for severe activity 0.90 (0.76-0.93). There was good concordance between FibroTest and LB (with discordance for two or more stages in <20% for advanced fibrosis and <10% for cirrhosis) and between ActiTest and LB. Specificity for FibroTest and ActiTest in the control population were 95% and 100% respectively.Fibrotest and ActiTest had high observed and standardized diagnostic values for predicting fibrosis and activity respectively." @default.
- W1497228230 created "2016-06-24" @default.
- W1497228230 creator A5030640744 @default.
- W1497228230 creator A5037763123 @default.
- W1497228230 creator A5047800489 @default.
- W1497228230 creator A5049775726 @default.
- W1497228230 creator A5053136097 @default.
- W1497228230 creator A5070077987 @default.
- W1497228230 creator A5077122217 @default.
- W1497228230 creator A5081786212 @default.
- W1497228230 creator A5082459656 @default.
- W1497228230 creator A5088051650 @default.
- W1497228230 date "2015-04-02" @default.
- W1497228230 modified "2023-09-27" @default.
- W1497228230 title "Noninvasive biomarkers FibroTest and ActiTest versus liver biopsy in chronic hepatitis C patients: the Middle East experience." @default.
- W1497228230 cites W1866422933 @default.
- W1497228230 cites W1964561230 @default.
- W1497228230 cites W1997026930 @default.
- W1497228230 cites W2000538721 @default.
- W1497228230 cites W2002163127 @default.
- W1497228230 cites W2004679437 @default.
- W1497228230 cites W2013085780 @default.
- W1497228230 cites W2015381959 @default.
- W1497228230 cites W2024123158 @default.
- W1497228230 cites W2027498662 @default.
- W1497228230 cites W2044269551 @default.
- W1497228230 cites W2050337410 @default.
- W1497228230 cites W2063929343 @default.
- W1497228230 cites W2082596496 @default.
- W1497228230 cites W2094174828 @default.
- W1497228230 cites W2118601935 @default.
- W1497228230 cites W2129736259 @default.
- W1497228230 cites W2135804606 @default.
- W1497228230 cites W2136336812 @default.
- W1497228230 cites W2139433036 @default.
- W1497228230 cites W2141672245 @default.
- W1497228230 cites W2147360611 @default.
- W1497228230 cites W2161397885 @default.
- W1497228230 cites W4211077792 @default.
- W1497228230 cites W85457612 @default.
- W1497228230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4367218" @default.
- W1497228230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25830472" @default.
- W1497228230 hasPublicationYear "2015" @default.
- W1497228230 type Work @default.
- W1497228230 sameAs 1497228230 @default.
- W1497228230 citedByCount "2" @default.
- W1497228230 countsByYear W14972282302018 @default.
- W1497228230 countsByYear W14972282302023 @default.
- W1497228230 crossrefType "journal-article" @default.
- W1497228230 hasAuthorship W1497228230A5030640744 @default.
- W1497228230 hasAuthorship W1497228230A5037763123 @default.
- W1497228230 hasAuthorship W1497228230A5047800489 @default.
- W1497228230 hasAuthorship W1497228230A5049775726 @default.
- W1497228230 hasAuthorship W1497228230A5053136097 @default.
- W1497228230 hasAuthorship W1497228230A5070077987 @default.
- W1497228230 hasAuthorship W1497228230A5077122217 @default.
- W1497228230 hasAuthorship W1497228230A5081786212 @default.
- W1497228230 hasAuthorship W1497228230A5082459656 @default.
- W1497228230 hasAuthorship W1497228230A5088051650 @default.
- W1497228230 hasConcept C126322002 @default.
- W1497228230 hasConcept C206396517 @default.
- W1497228230 hasConcept C2775934546 @default.
- W1497228230 hasConcept C2777214474 @default.
- W1497228230 hasConcept C2777513400 @default.
- W1497228230 hasConcept C2777766500 @default.
- W1497228230 hasConcept C2780559512 @default.
- W1497228230 hasConcept C58471807 @default.
- W1497228230 hasConcept C71924100 @default.
- W1497228230 hasConcept C90924648 @default.
- W1497228230 hasConceptScore W1497228230C126322002 @default.
- W1497228230 hasConceptScore W1497228230C206396517 @default.
- W1497228230 hasConceptScore W1497228230C2775934546 @default.
- W1497228230 hasConceptScore W1497228230C2777214474 @default.
- W1497228230 hasConceptScore W1497228230C2777513400 @default.
- W1497228230 hasConceptScore W1497228230C2777766500 @default.
- W1497228230 hasConceptScore W1497228230C2780559512 @default.
- W1497228230 hasConceptScore W1497228230C58471807 @default.
- W1497228230 hasConceptScore W1497228230C71924100 @default.
- W1497228230 hasConceptScore W1497228230C90924648 @default.
- W1497228230 hasIssue "2" @default.
- W1497228230 hasLocation W14972282301 @default.
- W1497228230 hasOpenAccess W1497228230 @default.
- W1497228230 hasPrimaryLocation W14972282301 @default.
- W1497228230 hasRelatedWork W2047081963 @default.
- W1497228230 hasRelatedWork W2104682956 @default.
- W1497228230 hasRelatedWork W2126552035 @default.
- W1497228230 hasRelatedWork W2160029914 @default.
- W1497228230 hasRelatedWork W2313149807 @default.
- W1497228230 hasRelatedWork W2382531208 @default.
- W1497228230 hasRelatedWork W2408792271 @default.
- W1497228230 hasRelatedWork W2603200842 @default.
- W1497228230 hasRelatedWork W2912054671 @default.
- W1497228230 hasRelatedWork W2953333168 @default.
- W1497228230 hasVolume "28" @default.
- W1497228230 isParatext "false" @default.
- W1497228230 isRetracted "false" @default.
- W1497228230 magId "1497228230" @default.
- W1497228230 workType "article" @default.