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• W1497247419 abstract "Background and Purpose Histamine and prostaglandin E 2 ( PGE 2 ), directly and via their effects on other cells, regulate the behaviour of vascular smooth muscle ( VSM ), but their effects on human VSM are incompletely resolved. Experimental Approach The effects of PGE 2 on histamine‐evoked changes in intracellular free Ca 2+ concentration ([ Ca 2+ ] i ) and adenylyl cyclase activity were measured in populations of cultured human aortic smooth muscle cells ( ASMCs ). Selective ligands of histamine and EP receptors were used to identify the receptors that mediate the responses. Key Results Histamine, via H 1 receptors, stimulates an increase in [ Ca 2+ ] i that is entirely mediated by activation of inositol 1,4,5‐trisphosphate receptors. Selective stimulation of EP 2 or EP 4 receptors attenuates histamine‐evoked Ca 2+ signals, but the effects of PGE 2 on both Ca 2+ signals and AC activity are largely mediated by EP 2 receptors. Conclusions and Implications Two important inflammatory mediators, histamine via H 1 receptors and PGE 2 acting largely via EP 2 receptors, exert opposing effects on [ Ca 2+ ] i in human ASMCs ." @default.
• W1497247419 created "2016-06-24" @default.
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• W1497247419 date "2013-07-12" @default.
• W1497247419 modified "2023-10-04" @default.
• W1497247419 title "<scp> <scp> Ca ²⁺ </scp> </scp> signals evoked by histamine <scp> H ₁ </scp> receptors are attenuated by activation of prostaglandin <scp> EP ₂ </scp> and <scp> EP ₄ </scp> receptors in human aortic smooth muscle cells" @default.
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• W1497247419 doi "https://doi.org/10.1111/bph.12239" @default.
• W1497247419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3724117" @default.
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• W1497247419 hasPublicationYear "2013" @default.
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