Matches in SemOpenAlex for { <https://semopenalex.org/work/W14972606> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W14972606 endingPage "6" @default.
- W14972606 startingPage "81" @default.
- W14972606 abstract "Thyroid carcinoma is the most common malignancy of the endocrine system and its incidence is still growing. The majority of thyroid tumors occur in sporadic form, however, some are inherited in families. The carcinomas can be divided into two groups according to the types of thyroid cells. Medullary thyroid carcinoma is derived from parafollicular C-cells. 20 - 25% of medullary thyroid carcinomas are inherited in multiple endocrine neoplasia type 2 syndromes. Genetic causes are activated by germ-line mutations in the RET proto-oncogene, which are transmitted autosomal, dominantly. At present the routine genetic screening and presymptomatic treatment (i.e. prophylactic total thyreoidectomy) on the basis of genotype-phenotype correlation has already been developed. The second group consists of carcinomas derived from follicular cells of thyroid that can be divided into differentiated (papillary and follicular) and nondifferentiated (anaplastic and poorly differentiated) ones. Also in this group 5-15% of carcinomas are cases of different familial syndromes (Gardner, Cowden, Werner syndromes and Carney complex) or only simple familial papillary thyroid carcinoma. Although the genetic basis of inherited cancer syndromes are mostly known (APC, PTEN, PRKAR1α and WRN genes), the cause of nonsyndromic familial papillary thyroid carcinoma is still under investigation, several predisposition genetic loci are recognized." @default.
- W14972606 created "2016-06-24" @default.
- W14972606 creator A5005167165 @default.
- W14972606 creator A5033228752 @default.
- W14972606 creator A5044162075 @default.
- W14972606 creator A5050849206 @default.
- W14972606 creator A5064297803 @default.
- W14972606 date "2014-04-01" @default.
- W14972606 modified "2023-09-23" @default.
- W14972606 title "[Hereditary thyroid carcinoma and its molecular diagnostics]." @default.
- W14972606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24758503" @default.
- W14972606 hasPublicationYear "2014" @default.
- W14972606 type Work @default.
- W14972606 sameAs 14972606 @default.
- W14972606 citedByCount "2" @default.
- W14972606 countsByYear W149726062014 @default.
- W14972606 crossrefType "journal-article" @default.
- W14972606 hasAuthorship W14972606A5005167165 @default.
- W14972606 hasAuthorship W14972606A5033228752 @default.
- W14972606 hasAuthorship W14972606A5044162075 @default.
- W14972606 hasAuthorship W14972606A5050849206 @default.
- W14972606 hasAuthorship W14972606A5064297803 @default.
- W14972606 hasConcept C104317684 @default.
- W14972606 hasConcept C126322002 @default.
- W14972606 hasConcept C13514818 @default.
- W14972606 hasConcept C142724271 @default.
- W14972606 hasConcept C2776667971 @default.
- W14972606 hasConcept C2779761222 @default.
- W14972606 hasConcept C2780103800 @default.
- W14972606 hasConcept C2780846426 @default.
- W14972606 hasConcept C2993294228 @default.
- W14972606 hasConcept C501734568 @default.
- W14972606 hasConcept C502942594 @default.
- W14972606 hasConcept C526584372 @default.
- W14972606 hasConcept C54355233 @default.
- W14972606 hasConcept C71924100 @default.
- W14972606 hasConcept C86803240 @default.
- W14972606 hasConceptScore W14972606C104317684 @default.
- W14972606 hasConceptScore W14972606C126322002 @default.
- W14972606 hasConceptScore W14972606C13514818 @default.
- W14972606 hasConceptScore W14972606C142724271 @default.
- W14972606 hasConceptScore W14972606C2776667971 @default.
- W14972606 hasConceptScore W14972606C2779761222 @default.
- W14972606 hasConceptScore W14972606C2780103800 @default.
- W14972606 hasConceptScore W14972606C2780846426 @default.
- W14972606 hasConceptScore W14972606C2993294228 @default.
- W14972606 hasConceptScore W14972606C501734568 @default.
- W14972606 hasConceptScore W14972606C502942594 @default.
- W14972606 hasConceptScore W14972606C526584372 @default.
- W14972606 hasConceptScore W14972606C54355233 @default.
- W14972606 hasConceptScore W14972606C71924100 @default.
- W14972606 hasConceptScore W14972606C86803240 @default.
- W14972606 hasIssue "2" @default.
- W14972606 hasLocation W149726061 @default.
- W14972606 hasOpenAccess W14972606 @default.
- W14972606 hasPrimaryLocation W149726061 @default.
- W14972606 hasRelatedWork W1569016369 @default.
- W14972606 hasRelatedWork W1970870200 @default.
- W14972606 hasRelatedWork W2076525872 @default.
- W14972606 hasRelatedWork W2093880388 @default.
- W14972606 hasRelatedWork W2101150934 @default.
- W14972606 hasRelatedWork W2412133561 @default.
- W14972606 hasRelatedWork W2606992035 @default.
- W14972606 hasRelatedWork W3017019859 @default.
- W14972606 hasRelatedWork W3118373417 @default.
- W14972606 hasRelatedWork W4214948555 @default.
- W14972606 hasVolume "50" @default.
- W14972606 isParatext "false" @default.
- W14972606 isRetracted "false" @default.
- W14972606 magId "14972606" @default.
- W14972606 workType "article" @default.