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• W1497273798 endingPage "10263" @default.
• W1497273798 startingPage "10253" @default.
• W1497273798 abstract "Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications. Herein, we demonstrate how the CuAAC method can provide novel phospholipid-protein conjugates with a high potential for the diagnostics and therapy of autoimmune conditions. In doing this, we, for the first time, covalently bind via 1,2,3-triazole linker biologically complementary molecules, namely phosphoethanol amine with human β2-glycoprotein I and prothrombin. The resulting phospholipid-protein conjugates show high binding affinity and specificity for the autoimmune antibodies against autoimmune complexes. Thus, the development of this work might become a milestone in further diagnostics and therapy of autoimmune diseases that involve the production of autoantibodies against the aforementioned phospholipids and proteins, such as antiphospholipid syndrome and systemic lupus erythematosus." @default.
• W1497273798 created "2016-06-24" @default.
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• W1497273798 date "2015-06-03" @default.
• W1497273798 modified "2023-10-09" @default.
• W1497273798 title "Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies" @default.
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• W1497273798 doi "https://doi.org/10.3390/molecules200610253" @default.
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• W1497273798 hasPublicationYear "2015" @default.
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