FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497282221> ?p ?o ?g. }

• W1497282221 endingPage "23657" @default.
• W1497282221 startingPage "23652" @default.
• W1497282221 abstract "Human and porcine factor VIII (fVIII) are activated by thrombin to form a heterotrimer composed of subunits designated A1 and A2 derived from the fVIII heavy chain (HC) and a subunit designated A3-C1-C2 derived from the fVIII light chain (LC). Human and porcine fVIII were activated at the same rate to the same peak levels but dissociation of the A2 subunit and concomitant loss of fVIIIa activity at pH 7.4 and 22 degrees C was 3-fold faster with human fVIIIa compared to porcine fVIIIa (0.35 min-1 versus 0.12 min-1, respectively). To determine structural requirements for the increased activity of porcine fVIII, plasma-derived hybrid human/porcine fVIII molecules were isolated. Porcine HC/human LC (pHC/hLC) fVIII had 44-fold higher coagulant activity than reconstituted human fVIII (hHC/hLC), 40-fold higher activity than hHC/pLC, and slightly (1.4-fold) higher activity than reconstituted porcine fVIII (pHC/pLC). Additionally, human and porcine A2 subunits and inactive A1/A3-C1-C2 human and porcine dimers were isolated and reconstitution experiments were done. Addition of the porcine A2 subunit to the human A1/A3-C1-C2 dimer produced coagulant activity similar to that found with porcine fVIIIa and superior to human fVIIIa. These results suggest that human fVIII has weaker coagulant activity than porcine fVIII due to faster dissociation of the A2 subunit and that the A2 subunit itself is responsible for the difference." @default.
• W1497282221 created "2016-06-24" @default.
• W1497282221 creator A5042202715 @default.
• W1497282221 creator A5053387578 @default.
• W1497282221 creator A5054167197 @default.
• W1497282221 date "1992-11-01" @default.
• W1497282221 modified "2023-10-14" @default.
• W1497282221 title "Coagulant properties of hybrid human/porcine factor VIII molecules." @default.
• W1497282221 cites W1497014448 @default.
• W1497282221 cites W1506286589 @default.
• W1497282221 cites W1525441378 @default.
• W1497282221 cites W1527081709 @default.
• W1497282221 cites W1533411169 @default.
• W1497282221 cites W1539663343 @default.
• W1497282221 cites W1539899414 @default.
• W1497282221 cites W1577204124 @default.
• W1497282221 cites W1577488314 @default.
• W1497282221 cites W1578596706 @default.
• W1497282221 cites W1598297039 @default.
• W1497282221 cites W1639438268 @default.
• W1497282221 cites W1963985231 @default.
• W1497282221 cites W1977048225 @default.
• W1497282221 cites W1984982908 @default.
• W1497282221 cites W2004412360 @default.
• W1497282221 cites W2021283345 @default.
• W1497282221 cites W2038058775 @default.
• W1497282221 cites W2038270465 @default.
• W1497282221 cites W2042932293 @default.
• W1497282221 cites W2054616813 @default.
• W1497282221 cites W2060670576 @default.
• W1497282221 cites W2061216302 @default.
• W1497282221 cites W2065336178 @default.
• W1497282221 cites W2071309611 @default.
• W1497282221 cites W2073305192 @default.
• W1497282221 cites W2082871970 @default.
• W1497282221 cites W2083974381 @default.
• W1497282221 cites W2091629675 @default.
• W1497282221 cites W2093662358 @default.
• W1497282221 cites W2100837269 @default.
• W1497282221 cites W2119460480 @default.
• W1497282221 cites W2151938814 @default.
• W1497282221 cites W2281427661 @default.
• W1497282221 cites W2337912069 @default.
• W1497282221 cites W2411143687 @default.
• W1497282221 cites W2413894884 @default.
• W1497282221 cites W2414779721 @default.
• W1497282221 cites W2418881382 @default.
• W1497282221 cites W2438513900 @default.
• W1497282221 cites W41642794 @default.
• W1497282221 cites W4297820747 @default.
• W1497282221 doi "https://doi.org/10.1016/s0021-9258(18)35888-5" @default.
• W1497282221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1429706" @default.
• W1497282221 hasPublicationYear "1992" @default.
• W1497282221 type Work @default.
• W1497282221 sameAs 1497282221 @default.
• W1497282221 citedByCount "113" @default.
• W1497282221 countsByYear W14972822212012 @default.
• W1497282221 countsByYear W14972822212013 @default.
• W1497282221 countsByYear W14972822212014 @default.
• W1497282221 countsByYear W14972822212015 @default.
• W1497282221 countsByYear W14972822212016 @default.
• W1497282221 countsByYear W14972822212017 @default.
• W1497282221 countsByYear W14972822212018 @default.
• W1497282221 countsByYear W14972822212019 @default.
• W1497282221 countsByYear W14972822212020 @default.
• W1497282221 countsByYear W14972822212021 @default.
• W1497282221 countsByYear W14972822212022 @default.
• W1497282221 countsByYear W14972822212023 @default.
• W1497282221 crossrefType "journal-article" @default.
• W1497282221 hasAuthorship W1497282221A5042202715 @default.
• W1497282221 hasAuthorship W1497282221A5053387578 @default.
• W1497282221 hasAuthorship W1497282221A5054167197 @default.
• W1497282221 hasBestOaLocation W14972822211 @default.
• W1497282221 hasConcept C12554922 @default.
• W1497282221 hasConcept C178790620 @default.
• W1497282221 hasConcept C185592680 @default.
• W1497282221 hasConcept C32909587 @default.
• W1497282221 hasConcept C55493867 @default.
• W1497282221 hasConcept C86803240 @default.
• W1497282221 hasConceptScore W1497282221C12554922 @default.
• W1497282221 hasConceptScore W1497282221C178790620 @default.
• W1497282221 hasConceptScore W1497282221C185592680 @default.
• W1497282221 hasConceptScore W1497282221C32909587 @default.
• W1497282221 hasConceptScore W1497282221C55493867 @default.
• W1497282221 hasConceptScore W1497282221C86803240 @default.
• W1497282221 hasIssue "33" @default.
• W1497282221 hasLocation W14972822211 @default.
• W1497282221 hasOpenAccess W1497282221 @default.
• W1497282221 hasPrimaryLocation W14972822211 @default.
• W1497282221 hasRelatedWork W1531601525 @default.
• W1497282221 hasRelatedWork W2319480705 @default.
• W1497282221 hasRelatedWork W2384464875 @default.
• W1497282221 hasRelatedWork W2606230654 @default.
• W1497282221 hasRelatedWork W2607424097 @default.
• W1497282221 hasRelatedWork W2748952813 @default.
• W1497282221 hasRelatedWork W2899084033 @default.
• W1497282221 hasRelatedWork W2948807893 @default.
• W1497282221 hasRelatedWork W4387497383 @default.

• next