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• W1497311279 startingPage "659" @default.
• W1497311279 abstract "Although current treatment modalities for malignant gliomas, such as surgery, radiation and chemotherapy, have been improved markedly in the past two decades, the prognosis of these neoplasms remains poor, the two year survival rate being approximately 5%. Therefore, alternative treatment options, such as gene therapy and immunotherapy are rapidly gaining momentum. One of the most promising immunotherapeutic approaches for the treatment of cancer is the vaccination of cancer patients with dendritic cells (DC) pulsed with tumor antigens. Immunotherapy with DC seems to be able to overcome, at least partially, the immunosuppressive state associated with primary malignant gliomas. DC therapy proved to be safe in both animal models and clinical trials. No serious side effects and no evidence of autoimmune toxicity occurred. Most studies used DC pulsed with an array of tumor-associated antigens rather than single peptides, to allow for presentation of unknown tumor-specific antigens to DC. Routes of administration either were subcutaneous, intradermal or intraperitoneal, with multiple injections of DC to enhance antitumor immunity. DC therapy as an adjuvant treatment for patients with malignant glioma seems to be biologically safe. Further clinical studies are warranted." @default.
• W1497311279 created "2016-06-24" @default.
• W1497311279 creator A5040483620 @default.
• W1497311279 creator A5057961107 @default.
• W1497311279 date "2001-10-01" @default.
• W1497311279 modified "2023-10-14" @default.
• W1497311279 title "Dendritic Cell Therapy of Primary Brain Tumors" @default.
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• W1497311279 doi "https://doi.org/10.1007/bf03401956" @default.
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