Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497331874> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1497331874 endingPage "4081" @default.
- W1497331874 startingPage "4075" @default.
- W1497331874 abstract "Abstract Spleen cells from B6.Tlaa (Qa-1a) mice primed against C57BL/6 (Qa-1b) splenocytes in vivo generate Qa-1-specific CTL when rechallenged with Qa-1b Ag in vitro. The addition of unirradiated Qa-1b splenocytes to these cultures inhibits the generation of Qa-1-specific CTL. By using highly purified cell populations, we demonstrate that the only cell population in resting spleen capable of causing this inhibition is NK1.1+. Although resting CD8 cells lack inhibitory activity, purified CD8 cells precultured with Con A and IL-2 inhibit anti-Qa-1 CTL. This inhibition is specific for the Qa-1b Ag expressed on the inhibitor cells, is not due to cold target competition, and is thus similar to that ascribed to veto cells. Although NK cells from resting spleen inhibit the generation of Qa-1-specific CTL, NK cells precultured in the presence of Con A and IL-2 show an approximate 30-fold increase in veto activity. Thus, NK cells represent the most likely cell population for down-regulating anti-self class I-reactive CTL." @default.
- W1497331874 created "2016-06-24" @default.
- W1497331874 creator A5025322340 @default.
- W1497331874 creator A5087255499 @default.
- W1497331874 date "1990-06-01" @default.
- W1497331874 modified "2023-10-16" @default.
- W1497331874 title "Regulation of the cytotoxic T lymphocyte response against Qa-1 alloantigens." @default.
- W1497331874 doi "https://doi.org/10.4049/jimmunol.144.11.4075" @default.
- W1497331874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2140385" @default.
- W1497331874 hasPublicationYear "1990" @default.
- W1497331874 type Work @default.
- W1497331874 sameAs 1497331874 @default.
- W1497331874 citedByCount "13" @default.
- W1497331874 countsByYear W14973318742013 @default.
- W1497331874 countsByYear W14973318742018 @default.
- W1497331874 crossrefType "journal-article" @default.
- W1497331874 hasAuthorship W1497331874A5025322340 @default.
- W1497331874 hasAuthorship W1497331874A5087255499 @default.
- W1497331874 hasBestOaLocation W14973318741 @default.
- W1497331874 hasConcept C147969180 @default.
- W1497331874 hasConcept C150903083 @default.
- W1497331874 hasConcept C153911025 @default.
- W1497331874 hasConcept C154317977 @default.
- W1497331874 hasConcept C167672396 @default.
- W1497331874 hasConcept C185592680 @default.
- W1497331874 hasConcept C189976730 @default.
- W1497331874 hasConcept C202751555 @default.
- W1497331874 hasConcept C203014093 @default.
- W1497331874 hasConcept C207001950 @default.
- W1497331874 hasConcept C2780931953 @default.
- W1497331874 hasConcept C2908647359 @default.
- W1497331874 hasConcept C55493867 @default.
- W1497331874 hasConcept C71924100 @default.
- W1497331874 hasConcept C86803240 @default.
- W1497331874 hasConcept C8891405 @default.
- W1497331874 hasConcept C99454951 @default.
- W1497331874 hasConceptScore W1497331874C147969180 @default.
- W1497331874 hasConceptScore W1497331874C150903083 @default.
- W1497331874 hasConceptScore W1497331874C153911025 @default.
- W1497331874 hasConceptScore W1497331874C154317977 @default.
- W1497331874 hasConceptScore W1497331874C167672396 @default.
- W1497331874 hasConceptScore W1497331874C185592680 @default.
- W1497331874 hasConceptScore W1497331874C189976730 @default.
- W1497331874 hasConceptScore W1497331874C202751555 @default.
- W1497331874 hasConceptScore W1497331874C203014093 @default.
- W1497331874 hasConceptScore W1497331874C207001950 @default.
- W1497331874 hasConceptScore W1497331874C2780931953 @default.
- W1497331874 hasConceptScore W1497331874C2908647359 @default.
- W1497331874 hasConceptScore W1497331874C55493867 @default.
- W1497331874 hasConceptScore W1497331874C71924100 @default.
- W1497331874 hasConceptScore W1497331874C86803240 @default.
- W1497331874 hasConceptScore W1497331874C8891405 @default.
- W1497331874 hasConceptScore W1497331874C99454951 @default.
- W1497331874 hasIssue "11" @default.
- W1497331874 hasLocation W14973318741 @default.
- W1497331874 hasLocation W14973318742 @default.
- W1497331874 hasOpenAccess W1497331874 @default.
- W1497331874 hasPrimaryLocation W14973318741 @default.
- W1497331874 hasRelatedWork W1483125918 @default.
- W1497331874 hasRelatedWork W1611619657 @default.
- W1497331874 hasRelatedWork W1980416103 @default.
- W1497331874 hasRelatedWork W1982694549 @default.
- W1497331874 hasRelatedWork W2018916009 @default.
- W1497331874 hasRelatedWork W2042647947 @default.
- W1497331874 hasRelatedWork W2054101033 @default.
- W1497331874 hasRelatedWork W2054329572 @default.
- W1497331874 hasRelatedWork W2330140392 @default.
- W1497331874 hasRelatedWork W2429231634 @default.
- W1497331874 hasVolume "144" @default.
- W1497331874 isParatext "false" @default.
- W1497331874 isRetracted "false" @default.
- W1497331874 magId "1497331874" @default.
- W1497331874 workType "article" @default.