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- W1497338732 abstract "In cultured mouse epidermal basal cells, retinoic acid is a potent inducer of transglutaminase, the enzyme responsible for isodipeptide bond formation in protein cross-linking in the production of the cornified membrane during terminal differentiation. Paradoxically retinoic acid also inhibits the formation of the cross-linked envelope and greatly reduces the level of dipeptide bond formation in epidermal cells induced to differentiate by calcium. These results suggest a novel mechanism by which retinoids can modify transglutaminase activity and epidermal differentiation." @default.
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- W1497338732 date "1982-09-01" @default.
- W1497338732 modified "2023-09-26" @default.
- W1497338732 title "Retinoic acid induces transglutaminase activity but inhibits cornification of cultured epidermal cells." @default.
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- W1497338732 doi "https://doi.org/10.1016/s0021-9258(18)33959-0" @default.
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