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- W1497372913 abstract "AbstractEver since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer’s disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.KeywordsAge-associated disordersAgingLifespanNAD intermediatesNAD worldNicotinamide adenine dinucleotideNicotinamide mononucleotideSIRT1SirtuinsSirtuin activating compounds" @default.
- W1497372913 created "2016-06-24" @default.
- W1497372913 creator A5012998559 @default.
- W1497372913 creator A5013140480 @default.
- W1497372913 creator A5081413351 @default.
- W1497372913 date "2011-01-01" @default.
- W1497372913 modified "2023-10-15" @default.
- W1497372913 title "The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity" @default.
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