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- W1497381195 abstract "Concentration profiles of signaling molecules, also known as morphogen gradients, play a critical role in the development of multi-cellular organisms by determining polarity and spatial patterning that leads to further tissue differentiation. Significant advances in studying morphogen gradients have been achieved recently when the formation of signaling molecules profiles has been visualized with high temporal and spatial resolution. A widely used approach to explain the establishment of concentration gradients assumes that signaling molecules are produced locally, then spread via a free diffusion and degraded uniformly. However, recent experiments have also produced controversial observations concerning the feasibility of this theoretical description. In addition, it has been shown that time to establish the morphogen gradient yield surprising linear scaling as a function of length, not expected for the systems with unbiased diffusion processes. Current theoretical views utilize continuum models that produce unphysical behavior at limiting cases. We propose here a theoretical approach based on discrete-state stochastic analysis that provides a possible microscopic mechanism of these complex phenomena. It is argued that relaxation times are mostly determined by first-passage times and the degradation effectively accelerates diffusion of signaling particles by removing slow moving molecules. Thus the degradation works as an effective potential that drives signaling molecules away from the source. Our theoretical analysis indicates that spatial and temporal features of degradation efficiently control the establishment of signaling molecules profiles." @default.
- W1497381195 created "2016-06-24" @default.
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- W1497381195 date "2014-06-09" @default.
- W1497381195 modified "2023-10-17" @default.
- W1497381195 title "How to Understand Morphogen Gradients Development during Biological Development" @default.
- W1497381195 hasPublicationYear "2014" @default.
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