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• W1497393946 endingPage "7642" @default.
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• W1497393946 abstract "The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch, pain, or itch. Despite the importance of these cells, our understanding of their roles in the neuronal circuitry is limited by the difficulty in identifying functional populations. One group that has been identified and characterized consists of cells in the mouse that express green fluorescent protein (GFP) under control of the prion protein (PrP) promoter. Previous reports suggested that PrP-GFP cells belonged to a single morphological class (central cells), received inputs exclusively from unmyelinated primary afferents, and had axons that remained in lamina II. However, we recently reported that the PrP-GFP cells expressed neuronal nitric oxide synthase (nNOS) and/or galanin, and it has been shown that nNOS-expressing cells are more diverse in their morphology and synaptic connections. We therefore used a combined electrophysiological, pharmacological, and anatomical approach to reexamine the PrP-GFP cells. We provide evidence that they are morphologically diverse (corresponding to unclassified cells) and receive synaptic input from a variety of primary afferents, with convergence onto individual cells. We also show that their axons project into adjacent laminae and that they target putative projection neurons in lamina I. This indicates that the neuronal circuitry involving PrP-GFP cells is more complex than previously recognized, and suggests that they are likely to have several distinct roles in regulating the flow of somatosensory information through the dorsal horn." @default.
• W1497393946 created "2016-06-24" @default.
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• W1497393946 date "2015-05-13" @default.
• W1497393946 modified "2023-10-15" @default.
• W1497393946 title "Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets" @default.
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• W1497393946 doi "https://doi.org/10.1523/jneurosci.0406-15.2015" @default.
• W1497393946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4429159" @default.
• W1497393946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972186" @default.
• W1497393946 hasPublicationYear "2015" @default.
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