Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497394985> ?p ?o ?g. }
- W1497394985 endingPage "213" @default.
- W1497394985 startingPage "187" @default.
- W1497394985 abstract "Membrane proteins are a large, diverse group of proteins, representing about 20–30% of the proteomes of most organisms, serving a multitude of cellular functions and more than 40% of drug targets. Knowledge of a membrane protein structure enables us insight into its function and dynamics, and can be used for further rational drug design. Owing to the intrinsic hydrophobicity, flexibility, and instability of membrane proteins, solid-state NMR may offer an unique opportunity to study membrane protein structure, ligand binding, and activation at atomic resolution in the native membrane environment on a wide ranging time scale. Over the past several years, solid-state NMR has made tremendous progress, showing its capability of determining membrane protein structure, ligand binding, and protein dynamic conformation on a variety of time scales at atomic resolution. In this chapter we will mainly discuss some recent achievements on membrane protein structure determination, ligand conformation and binding, structure changes upon activation, and structure of insoluble fibrous proteins investigated by using magic-angle spinning solid-state NMR from the structural biology point of view. Protein dynamics, sensitivity enhancement, and the possibility of chemical shift-based structure determination in solid-state NMR are also briefly touched upon." @default.
- W1497394985 created "2016-06-24" @default.
- W1497394985 creator A5026499832 @default.
- W1497394985 date "2011-01-01" @default.
- W1497394985 modified "2023-09-24" @default.
- W1497394985 title "Protein Structure Determination by Solid-State NMR" @default.
- W1497394985 cites W103671729 @default.
- W1497394985 cites W1505145030 @default.
- W1497394985 cites W1508259544 @default.
- W1497394985 cites W1589295940 @default.
- W1497394985 cites W1908561802 @default.
- W1497394985 cites W1940787904 @default.
- W1497394985 cites W1964183942 @default.
- W1497394985 cites W1964235989 @default.
- W1497394985 cites W1964458361 @default.
- W1497394985 cites W1965346021 @default.
- W1497394985 cites W1965476055 @default.
- W1497394985 cites W1966420704 @default.
- W1497394985 cites W1966438745 @default.
- W1497394985 cites W1966910457 @default.
- W1497394985 cites W1968240084 @default.
- W1497394985 cites W1971749499 @default.
- W1497394985 cites W1973036661 @default.
- W1497394985 cites W1973479349 @default.
- W1497394985 cites W1973907865 @default.
- W1497394985 cites W1974233292 @default.
- W1497394985 cites W1976142948 @default.
- W1497394985 cites W1976160537 @default.
- W1497394985 cites W1976744778 @default.
- W1497394985 cites W1977437793 @default.
- W1497394985 cites W1977579538 @default.
- W1497394985 cites W1977754106 @default.
- W1497394985 cites W1977891118 @default.
- W1497394985 cites W1978545297 @default.
- W1497394985 cites W1980502007 @default.
- W1497394985 cites W1980567977 @default.
- W1497394985 cites W1980642774 @default.
- W1497394985 cites W1980962873 @default.
- W1497394985 cites W1983301918 @default.
- W1497394985 cites W1983521156 @default.
- W1497394985 cites W1985531283 @default.
- W1497394985 cites W1985911254 @default.
- W1497394985 cites W1987131886 @default.
- W1497394985 cites W1987518658 @default.
- W1497394985 cites W1989256279 @default.
- W1497394985 cites W1989695304 @default.
- W1497394985 cites W1989971979 @default.
- W1497394985 cites W1990122271 @default.
- W1497394985 cites W1991757508 @default.
- W1497394985 cites W1991898882 @default.
- W1497394985 cites W1992740910 @default.
- W1497394985 cites W1994609929 @default.
- W1497394985 cites W1997624421 @default.
- W1497394985 cites W1998225371 @default.
- W1497394985 cites W1999353132 @default.
- W1497394985 cites W2000510012 @default.
- W1497394985 cites W2000703629 @default.
- W1497394985 cites W2002590816 @default.
- W1497394985 cites W2002869713 @default.
- W1497394985 cites W2003560901 @default.
- W1497394985 cites W2003966981 @default.
- W1497394985 cites W2004098528 @default.
- W1497394985 cites W2004360966 @default.
- W1497394985 cites W2005801417 @default.
- W1497394985 cites W2006719424 @default.
- W1497394985 cites W2006769412 @default.
- W1497394985 cites W2007256004 @default.
- W1497394985 cites W2009845771 @default.
- W1497394985 cites W2011698799 @default.
- W1497394985 cites W2013767643 @default.
- W1497394985 cites W2013836769 @default.
- W1497394985 cites W2013956444 @default.
- W1497394985 cites W2014000361 @default.
- W1497394985 cites W2014228264 @default.
- W1497394985 cites W2014784084 @default.
- W1497394985 cites W2015117663 @default.
- W1497394985 cites W2015214828 @default.
- W1497394985 cites W2015788314 @default.
- W1497394985 cites W2019127523 @default.
- W1497394985 cites W2020601776 @default.
- W1497394985 cites W2021428604 @default.
- W1497394985 cites W2022252221 @default.
- W1497394985 cites W2022734206 @default.
- W1497394985 cites W2024832918 @default.
- W1497394985 cites W2024859787 @default.
- W1497394985 cites W2025638816 @default.
- W1497394985 cites W2026469255 @default.
- W1497394985 cites W2026871964 @default.
- W1497394985 cites W2027569419 @default.
- W1497394985 cites W2031034110 @default.
- W1497394985 cites W2031436470 @default.
- W1497394985 cites W2031934954 @default.
- W1497394985 cites W2032525701 @default.
- W1497394985 cites W2032907555 @default.
- W1497394985 cites W2033019961 @default.
- W1497394985 cites W2033155339 @default.
- W1497394985 cites W2035187915 @default.
- W1497394985 cites W2036921365 @default.