FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497397737> ?p ?o ?g. }

• W1497397737 abstract "Software engineering designs and practices differ widely among various application domains. This chapter is concentrating on high performance software engineering design for bioinformatics and more specifically for diabetes mellitus study through gene and retinopathy analysis. Complex gene interaction study offers an effective control of blood glucose, blood pressure and lipids. Early detection of retinopathy is effective in minimizing the risk of irreversible vision loss and other long-term consequence associated with diabetes mellitus. Type 2 diabetes mellitus is a disorder of glucose homeostasis involving complex gene and environmental interactions that are incompletely understood. Mammalian homologs of nematode sex determination genes have recently been implicated in glucose homeostasis and type 2 diabetes mellitus. The Fem1b knockout (Fem1b-KO) mice have been developed, with targeted inactivation of Fem1b, a homolog of the nematode fem-1 sex determination gene. It shows that the Fem1b-KO mice display abnormal glucose tolerance and that this is due predominantly to defective glucose-stimulated insulin secretion. Arginine-stimulated insulin secretion is also affected. These data implicate Fem1b in pancreatic islet function and insulin secretion, strengthening evidence that a genetic pathway homologous to nematode sex determination may be involved in glucose homeostasis and suggesting novel genes and processes as potential candidates in the pathogenesis of diabetes mellitus. In addition, this chapter is going to introduce basic gene analysis approaches that can be applied on diabetes mellitus study. These approaches include searching Genbank online database using BLAST, mapping DNA, locating genes, aligning different DNA or protein sequences, determining genotypes, and comparing nucleotide or amino acid sequences using global and local alignment algorithms. Fem1b gene, as an example, is going to be discussed with these basic gene analysis approaches. Diabetic retinopathy is the leading cause of new cases of blindness among Americans aged 20 to 64 in both predominantly white and black populations [1]. Despite the recommendation for yearly eye examinations and efforts to achieve this, of the approximately 17 million Americans with diabetes, about 6 million nationwide remain undiagnosed and untreated, or not receiving annual eye examinations, which can lead to diabetic retinopathy [2]. Early indications of retinal blood vessel abnormalities and complications provide important indicators for clinical timely diagnosis and treatment of diabetes mellitus and eye disorders. The software engineering design tool facilitates increasing the number of annual diabetic" @default.
• W1497397737 created "2016-06-24" @default.
• W1497397737 creator A5015839626 @default.
• W1497397737 creator A5047090298 @default.
• W1497397737 creator A5077560740 @default.
• W1497397737 date "2012-01-20" @default.
• W1497397737 modified "2023-10-01" @default.
• W1497397737 title "Domain-Specific Software Engineering Design for Diabetes Mellitus Study Through Gene and Retinopathy Analysis" @default.
• W1497397737 cites W1545502161 @default.
• W1497397737 cites W1547662774 @default.
• W1497397737 cites W172590221 @default.
• W1497397737 cites W1967245034 @default.
• W1497397737 cites W1972527753 @default.
• W1497397737 cites W1993931991 @default.
• W1497397737 cites W2026145411 @default.
• W1497397737 cites W2046433337 @default.
• W1497397737 cites W2067921689 @default.
• W1497397737 cites W2074231493 @default.
• W1497397737 cites W2087064593 @default.
• W1497397737 cites W2094564248 @default.
• W1497397737 cites W2117825948 @default.
• W1497397737 cites W2126584664 @default.
• W1497397737 cites W2145023731 @default.
• W1497397737 cites W2146266151 @default.
• W1497397737 cites W2155378236 @default.
• W1497397737 cites W2783254321 @default.
• W1497397737 doi "https://doi.org/10.5772/20555" @default.
• W1497397737 hasPublicationYear "2012" @default.
• W1497397737 type Work @default.
• W1497397737 sameAs 1497397737 @default.
• W1497397737 citedByCount "0" @default.
• W1497397737 crossrefType "book-chapter" @default.
• W1497397737 hasAuthorship W1497397737A5015839626 @default.
• W1497397737 hasAuthorship W1497397737A5047090298 @default.
• W1497397737 hasAuthorship W1497397737A5077560740 @default.
• W1497397737 hasBestOaLocation W14973977371 @default.
• W1497397737 hasConcept C104317684 @default.
• W1497397737 hasConcept C134018914 @default.
• W1497397737 hasConcept C2777391703 @default.
• W1497397737 hasConcept C2779306644 @default.
• W1497397737 hasConcept C2910068830 @default.
• W1497397737 hasConcept C3018667095 @default.
• W1497397737 hasConcept C54355233 @default.
• W1497397737 hasConcept C555293320 @default.
• W1497397737 hasConcept C60644358 @default.
• W1497397737 hasConcept C86803240 @default.
• W1497397737 hasConceptScore W1497397737C104317684 @default.
• W1497397737 hasConceptScore W1497397737C134018914 @default.
• W1497397737 hasConceptScore W1497397737C2777391703 @default.
• W1497397737 hasConceptScore W1497397737C2779306644 @default.
• W1497397737 hasConceptScore W1497397737C2910068830 @default.
• W1497397737 hasConceptScore W1497397737C3018667095 @default.
• W1497397737 hasConceptScore W1497397737C54355233 @default.
• W1497397737 hasConceptScore W1497397737C555293320 @default.
• W1497397737 hasConceptScore W1497397737C60644358 @default.
• W1497397737 hasConceptScore W1497397737C86803240 @default.
• W1497397737 hasLocation W14973977371 @default.
• W1497397737 hasOpenAccess W1497397737 @default.
• W1497397737 hasPrimaryLocation W14973977371 @default.
• W1497397737 hasRelatedWork W1994621985 @default.
• W1497397737 hasRelatedWork W2009330094 @default.
• W1497397737 hasRelatedWork W2039632689 @default.
• W1497397737 hasRelatedWork W2122484052 @default.
• W1497397737 hasRelatedWork W2293183915 @default.
• W1497397737 hasRelatedWork W2339884616 @default.
• W1497397737 hasRelatedWork W2379758848 @default.
• W1497397737 hasRelatedWork W2401641736 @default.
• W1497397737 hasRelatedWork W2409271173 @default.
• W1497397737 hasRelatedWork W2465563984 @default.
• W1497397737 hasRelatedWork W2503586860 @default.
• W1497397737 hasRelatedWork W2560755766 @default.
• W1497397737 hasRelatedWork W25782933 @default.
• W1497397737 hasRelatedWork W2768519410 @default.
• W1497397737 hasRelatedWork W2774006386 @default.
• W1497397737 hasRelatedWork W3016412114 @default.
• W1497397737 hasRelatedWork W3029994953 @default.
• W1497397737 hasRelatedWork W3031877548 @default.
• W1497397737 hasRelatedWork W3040873899 @default.
• W1497397737 hasRelatedWork W3198196705 @default.
• W1497397737 isParatext "false" @default.
• W1497397737 isRetracted "false" @default.
• W1497397737 magId "1497397737" @default.
• W1497397737 workType "book-chapter" @default.