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• W1497403334 endingPage "7301" @default.
• W1497403334 startingPage "7294" @default.
• W1497403334 abstract "ABSTRACT The latency-related transcript (LRT) of bovine herpesvirus 1 (BHV-1) is the only abundant viral RNA detected during latency. A previous study (A. Hossain, L. M. Schang, and C. Jones, J. Virol. 69:5345–5352, 1995) concluded that splicing of polyadenylated [poly(A) + ] and splicing of nonpolyadenylated [poly(A) − ] LRT are different. In this study, splice junction sites of LRT were identified. In trigeminal ganglia of acutely infected calves (1, 7, or 15 days postinfection [p.i.]) or in latently infected calves (60 days p.i.), alternative splicing of poly(A) + LRT occurred. Productive viral gene expression in trigeminal ganglia is readily detected from 2 to 7 days p.i. but not at 15 days p.i. (L. M. Schang and C. Jones, J. Virol. 71:6786–6795, 1997), suggesting that certain aspects of a lytic infection occur in neurons and that these factors influence LRT splicing. Splicing of poly(A) − LRT was also detected in transfected COS-7 cells or infected MDBK cells. DNA sequence analysis of spliced LRT cDNAs, poly(A) + or poly(A) − , revealed nonconsensus splice signals at exon/intron and intron/exon boundaries. The GC-AG splicing signal utilized by the herpes simplex virus type 1 latency-associated transcript in latently infected mice is also used by LRT in latently infected calves. Taken together, these results led us to hypothesize that (i) poly(A) + LRT is spliced in trigeminal ganglia by neuron-specific factors, (ii) viral or virus-induced factors participate in splicing, and (iii) alternative splicing of LRT may result in protein isoforms which have novel biological properties." @default.
• W1497403334 created "2016-06-24" @default.
• W1497403334 creator A5020518181 @default.
• W1497403334 creator A5064487027 @default.
• W1497403334 date "1998-09-01" @default.
• W1497403334 modified "2023-10-10" @default.
• W1497403334 title "Alternative Splicing of the Latency-Related Transcript of Bovine Herpesvirus 1 Yields RNAs Containing Unique Open Reading Frames" @default.
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• W1497403334 doi "https://doi.org/10.1128/jvi.72.9.7294-7301.1998" @default.
• W1497403334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109953" @default.
• W1497403334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9696825" @default.
• W1497403334 hasPublicationYear "1998" @default.
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