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- W1497410183 abstract "Abstract The ceramide family of lipids plays important roles in both cell structure and signaling in a diverse array of cell types, including immune cells. However, very little is known regarding how ceramide affects the activation of dendritic cells (DCs) in response to viral infection. In this study, we demonstrate that a synthetic ceramide analog (C8) stimulates DCs to increase the expansion of virus-specific T cells upon virus infection. Exogenously supplied C8 ceramide elevated the expression of DC maturation markers such as MHC class I and costimulatory molecules following infection with the clone 13 strain of lymphocytic choriomeningitis virus (LCMV) or influenza virus. Importantly, ceramide-conditioned, LCMV-infected DCs displayed an increased ability to promote expansion of virus-specific CD8+ T cells when compared with virus-infected DCs. Furthermore, a locally instilled ceramide analog significantly increased virus-reactive T cell responses in vivo to both LCMV and influenza virus infections. Collectively, these findings provide new insights into ceramide-mediated regulation of DC responses against virus infection and help us establish a foundation for novel immune-stimulatory therapeutics." @default.
- W1497410183 created "2016-06-24" @default.
- W1497410183 creator A5033601183 @default.
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- W1497410183 creator A5062965636 @default.
- W1497410183 creator A5069654591 @default.
- W1497410183 date "2015-05-01" @default.
- W1497410183 modified "2023-10-16" @default.
- W1497410183 title "A Ceramide Analogue Stimulates Dendritic Cells To Promote T Cell Responses upon Virus Infections" @default.
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- W1497410183 doi "https://doi.org/10.4049/jimmunol.1402672" @default.
- W1497410183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4402267" @default.
- W1497410183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25810392" @default.
- W1497410183 hasPublicationYear "2015" @default.
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