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• W1497451448 endingPage "608" @default.
• W1497451448 startingPage "600" @default.
• W1497451448 abstract "Fluctuation of ion current, between a high conductance and a low conductance state, through biological ion channels and pores is assumed to arise from conformational changes between an open and a closed configuration. Here we offer an additional mechanism that arises from changes in ionization of fixed charges within, or at the mouth of, a channel or pore. Our hypothesis, which is based on measurements of ion selectivity alongside ion current, applies to pores through some synthetic membranes and through channels-such as those created by certain toxins-that remain (at least partially) open in the low conductance state. It may also explain the phenomena of open channel noise and substate behavior that characterize several endogenous ion channels and should be considered when modeling the behavior of such channels." @default.
• W1497451448 created "2016-06-24" @default.
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• W1497451448 date "1997-06-01" @default.
• W1497451448 modified "2023-09-26" @default.
• W1497451448 title "A novel explanation for fluctuations of ion current through narrow pores" @default.
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• W1497451448 doi "https://doi.org/10.1096/fasebj.11.7.9212084" @default.
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• W1497451448 hasPublicationYear "1997" @default.
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