FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497458097> ?p ?o ?g. }

• W1497458097 endingPage "620" @default.
• W1497458097 startingPage "609" @default.
• W1497458097 abstract "Heterocyclic aromatic amines (HAAs), carcinogens produced in meat when cooked at high temperatures, are an emerging biologic explanation for the meat‐colorectal cancer relationship. HAAs form DNA adducts; left unrepaired, adducts can induce mutations, which may initiate/promote carcinogenesis. The purpose of this research was to investigate the relationship between dietary HAAs, genetic susceptibility and bulky DNA adduct levels. Least squares regression was used to examine the relationship between dietary HAA exposure and bulky DNA adduct levels in blood measured using 32 P‐postlabeling among 99 healthy volunteers. Gene‐diet interactions between dietary HAAs and genetic factors relevant to the biotransformation of HAAs and DNA repair were also examined. No main effects of dietary HAAs on bulky DNA adduct levels was found. However, those with the putative NAT1 rapid acetylator phenotype had lower adduct levels than those with the slow acetylator phenotype ( P = 0.02). Furthermore, having five or more 'at‐risk' genotypes was associated with higher bulky DNA adduct levels ( P = 0.03). Gene‐diet interactions were observed between NAT1 polymorphisms and dietary HAAs ( P < 0.05); among the slow acetylator phenotype, higher intakes of HAAs were associated with an increase in DNA adduct levels compared to lower intakes. This study provides evidence of a biologic relationship between dietary HAAs, genetic susceptibility and bulky DNA adduct formation. However, the lack of a strong main effect of HAAs suggests that dietary HAAs are not a large contributor to bulky DNA adducts in this population; future studies should consider relevant gene‐diet interactions to clarify the role of HAAs in carcinogenesis. Environ. Mol. Mutagen. 56:609–620, 2015. © 2015 Wiley Periodicals, Inc." @default.
• W1497458097 created "2016-06-24" @default.
• W1497458097 creator A5003255529 @default.
• W1497458097 creator A5014817206 @default.
• W1497458097 creator A5035861090 @default.
• W1497458097 creator A5038697595 @default.
• W1497458097 creator A5066337396 @default.
• W1497458097 creator A5089411633 @default.
• W1497458097 creator A5091760825 @default.
• W1497458097 date "2015-05-22" @default.
• W1497458097 modified "2023-10-14" @default.
• W1497458097 title "Gene-diet interactions in exposure to heterocyclic aromatic amines and bulky DNA adduct levels in blood leukocytes" @default.
• W1497458097 cites W1537914369 @default.
• W1497458097 cites W1593346363 @default.
• W1497458097 cites W1960955924 @default.
• W1497458097 cites W1965867315 @default.
• W1497458097 cites W1969802369 @default.
• W1497458097 cites W1971214797 @default.
• W1497458097 cites W1974642640 @default.
• W1497458097 cites W1991979813 @default.
• W1497458097 cites W1996132242 @default.
• W1497458097 cites W2001806507 @default.
• W1497458097 cites W2012900875 @default.
• W1497458097 cites W2022756559 @default.
• W1497458097 cites W2026453554 @default.
• W1497458097 cites W2029557628 @default.
• W1497458097 cites W2031932681 @default.
• W1497458097 cites W2033631600 @default.
• W1497458097 cites W2033741635 @default.
• W1497458097 cites W2038896282 @default.
• W1497458097 cites W2044801902 @default.
• W1497458097 cites W2045892119 @default.
• W1497458097 cites W2046741367 @default.
• W1497458097 cites W2047480828 @default.
• W1497458097 cites W2047934584 @default.
• W1497458097 cites W2050276116 @default.
• W1497458097 cites W2056355462 @default.
• W1497458097 cites W2060273330 @default.
• W1497458097 cites W2061382434 @default.
• W1497458097 cites W2067231362 @default.
• W1497458097 cites W2071650385 @default.
• W1497458097 cites W2072090020 @default.
• W1497458097 cites W2075802734 @default.
• W1497458097 cites W2079931352 @default.
• W1497458097 cites W2081012263 @default.
• W1497458097 cites W2083384714 @default.
• W1497458097 cites W2085547281 @default.
• W1497458097 cites W2091817272 @default.
• W1497458097 cites W2092021402 @default.
• W1497458097 cites W2100919773 @default.
• W1497458097 cites W2101398264 @default.
• W1497458097 cites W2102688623 @default.
• W1497458097 cites W2105217785 @default.
• W1497458097 cites W2105770609 @default.
• W1497458097 cites W2106028933 @default.
• W1497458097 cites W2107287791 @default.
• W1497458097 cites W2111770217 @default.
• W1497458097 cites W2111833665 @default.
• W1497458097 cites W2113603184 @default.
• W1497458097 cites W2115857994 @default.
• W1497458097 cites W2120487908 @default.
• W1497458097 cites W2122696589 @default.
• W1497458097 cites W2127146955 @default.
• W1497458097 cites W2131611693 @default.
• W1497458097 cites W2134199999 @default.
• W1497458097 cites W2134628271 @default.
• W1497458097 cites W2143032232 @default.
• W1497458097 cites W2145958344 @default.
• W1497458097 cites W2152401054 @default.
• W1497458097 cites W2153189003 @default.
• W1497458097 cites W2153211360 @default.
• W1497458097 cites W2154399177 @default.
• W1497458097 cites W2157027674 @default.
• W1497458097 cites W2159611805 @default.
• W1497458097 cites W2165150104 @default.
• W1497458097 cites W2169581934 @default.
• W1497458097 cites W2189515476 @default.
• W1497458097 cites W4246230065 @default.
• W1497458097 doi "https://doi.org/10.1002/em.21950" @default.
• W1497458097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26010176" @default.
• W1497458097 hasPublicationYear "2015" @default.
• W1497458097 type Work @default.
• W1497458097 sameAs 1497458097 @default.
• W1497458097 citedByCount "8" @default.
• W1497458097 countsByYear W14974580972017 @default.
• W1497458097 countsByYear W14974580972018 @default.
• W1497458097 countsByYear W14974580972019 @default.
• W1497458097 countsByYear W14974580972021 @default.
• W1497458097 countsByYear W14974580972023 @default.
• W1497458097 crossrefType "journal-article" @default.
• W1497458097 hasAuthorship W1497458097A5003255529 @default.
• W1497458097 hasAuthorship W1497458097A5014817206 @default.
• W1497458097 hasAuthorship W1497458097A5035861090 @default.
• W1497458097 hasAuthorship W1497458097A5038697595 @default.
• W1497458097 hasAuthorship W1497458097A5066337396 @default.
• W1497458097 hasAuthorship W1497458097A5089411633 @default.
• W1497458097 hasAuthorship W1497458097A5091760825 @default.
• W1497458097 hasConcept C104317684 @default.

• next