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- W1497505837 abstract "The AMPA-preferring subtype of ionotropic glutamate receptors (GluRs) is a hetero-oligomeric ion channel assembled from various combinations of four subunits: GluR1, GluR2, GluR3, and GluR4. Antagonists of these receptors can mitigate the effects of experimental spinal cord injury (SCI), indicating that these receptors play a significant role in pathophysiology after spinal trauma. We tested the hypothesis that SCI alters expression of AMPA receptors using a standardized thoracic weight-drop model of rat contusive spinal cord injury. AMPA receptor subunit expression was measured at 24 hr and at 1 month after SCI with quantitative Western blot analysis and in situ hybridization. GluR2 protein levels were preferentially reduced near the injury site 24 hr after SCI. This reduction persisted at 1 month. At a cellular level, a significant decrease in both GluR2 and GluR4 mRNA was found in spared ventral motor neurons adjacent to the injury site and distal to it, with other AMPA subunit mRNAs maintained at control levels. In contrast, only GluR1 mRNA was decreased in the sympathetic preganglionic neurons of the intermediolateral horn. These results suggest population-specific and long-lasting changes in neuronal AMPA receptor composition, which may alter response to glutamate after SCI. These alterations may contribute not only to acute neuropathological consequences of injury, but they may also be partially responsible for the altered functional state of preserved tissue seen chronically after SCI." @default.
- W1497505837 created "2016-06-24" @default.
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- W1497505837 creator A5079401671 @default.
- W1497505837 creator A5080438436 @default.
- W1497505837 creator A5091878324 @default.
- W1497505837 date "1999-07-15" @default.
- W1497505837 modified "2023-09-29" @default.
- W1497505837 title "Alterations in AMPA Receptor Subunit Expression after Experimental Spinal Cord Contusion Injury" @default.
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- W1497505837 doi "https://doi.org/10.1523/jneurosci.19-14-05711.1999" @default.
- W1497505837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6783105" @default.
- W1497505837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10407012" @default.
- W1497505837 hasPublicationYear "1999" @default.
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