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- W1497642289 abstract "Mizoribine is an immunosuppressive drug (4-carbamoyl-1-ß-Dribofuranosylimidazolium-5-olate, also known as bredinin) which has been demonstrated to be beneficial in organ transplantation. In animal models: canine renal allografts, and rat cardiac and partial lung allografts, mizoribine is synergistic with cyclosporine in prolonging survival1,2. Mizoribine has been proven to be clinically useful for human renal transplantation as part of two or three drug therapy3. The results are comparable or superior to azathioprine; however mizoribine does not cause myelosuppresion or hepatotoxicity. Mizoribine is a nucleoside antibiotic isolated from a soil fungus, Eupenicillum brefeldianum. Mizoribine is phosphorylated to mizoribine monophosphate by adenosine kinase and the monophosphate is postulated to inhibit inosine monophosphate dehydrogenase (EC1.2.1.14)4,5. The predicted depletion of guanine ribonucleotides may block T cell proliferation by preventing signal transduction or act at some more distal point in the activation pathway." @default.
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- W1497642289 date "1991-01-01" @default.
- W1497642289 modified "2023-09-24" @default.
- W1497642289 title "Guanine Ribonucleotide Depletion Inhibits T Cell Activation" @default.
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- W1497642289 doi "https://doi.org/10.1007/978-1-4615-7703-4_65" @default.
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