FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497659049> ?p ?o ?g. }

• W1497659049 endingPage "181" @default.
• W1497659049 startingPage "181" @default.
• W1497659049 abstract "We introduce Synoviolin as a novel pathogenic factor in rheumatoid arthritis (RA). Experimental studies indicate that this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis. Overexpression of Synoviolin in mice causes arthropathy with synovial hyperplasia, whereas heterozygous knockdown results in increased apoptosis of synovial cells and resistance to collagen-induced arthritis in mice. On the basis of these experimental data, we propose that excess elimination of unfolded proteins (that is, 'hyper-ERAD') by overexpression of Synoviolin triggers synovial cell overgrowth and hence a worsening of RA. Further analysis of the hyper-ERAD system may permit the complex pathomechanisms of RA to be uncovered." @default.
• W1497659049 created "2016-06-24" @default.
• W1497659049 creator A5015262464 @default.
• W1497659049 creator A5020071691 @default.
• W1497659049 creator A5035937928 @default.
• W1497659049 creator A5056681640 @default.
• W1497659049 creator A5090769439 @default.
• W1497659049 date "2005-01-01" @default.
• W1497659049 modified "2023-10-07" @default.
• W1497659049 cites W1496639644 @default.
• W1497659049 cites W1504496748 @default.
• W1497659049 cites W1575978940 @default.
• W1497659049 cites W178670659 @default.
• W1497659049 cites W1906283391 @default.
• W1497659049 cites W1980485419 @default.
• W1497659049 cites W1993040702 @default.
• W1497659049 cites W1994696611 @default.
• W1497659049 cites W1995257728 @default.
• W1497659049 cites W1997369314 @default.
• W1497659049 cites W1999124126 @default.
• W1497659049 cites W2002439304 @default.
• W1497659049 cites W2007422965 @default.
• W1497659049 cites W2013304672 @default.
• W1497659049 cites W2020124645 @default.
• W1497659049 cites W2022376508 @default.
• W1497659049 cites W2039824115 @default.
• W1497659049 cites W2044578185 @default.
• W1497659049 cites W2045151558 @default.
• W1497659049 cites W2047201865 @default.
• W1497659049 cites W2058177171 @default.
• W1497659049 cites W2061614901 @default.
• W1497659049 cites W2070379968 @default.
• W1497659049 cites W2075965568 @default.
• W1497659049 cites W2084944302 @default.
• W1497659049 cites W2090839709 @default.
• W1497659049 cites W2097868610 @default.
• W1497659049 cites W2102859558 @default.
• W1497659049 cites W2103764114 @default.
• W1497659049 cites W2121313537 @default.
• W1497659049 cites W2137075815 @default.
• W1497659049 cites W2137208120 @default.
• W1497659049 cites W2137755719 @default.
• W1497659049 cites W2139577310 @default.
• W1497659049 cites W2142780460 @default.
• W1497659049 cites W2145922063 @default.
• W1497659049 cites W2147336345 @default.
• W1497659049 cites W2148301853 @default.
• W1497659049 cites W2152398979 @default.
• W1497659049 cites W2153458899 @default.
• W1497659049 cites W2160731095 @default.
• W1497659049 cites W4236183098 @default.
• W1497659049 doi "https://doi.org/10.1186/ar1808" @default.
• W1497659049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1257448" @default.
• W1497659049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16207344" @default.
• W1497659049 hasPublicationYear "2005" @default.
• W1497659049 type Work @default.
• W1497659049 sameAs 1497659049 @default.
• W1497659049 citedByCount "53" @default.
• W1497659049 countsByYear W14976590492012 @default.
• W1497659049 countsByYear W14976590492013 @default.
• W1497659049 countsByYear W14976590492014 @default.
• W1497659049 countsByYear W14976590492015 @default.
• W1497659049 countsByYear W14976590492016 @default.
• W1497659049 countsByYear W14976590492018 @default.
• W1497659049 countsByYear W14976590492019 @default.
• W1497659049 countsByYear W14976590492020 @default.
• W1497659049 countsByYear W14976590492021 @default.
• W1497659049 countsByYear W14976590492022 @default.
• W1497659049 countsByYear W14976590492023 @default.
• W1497659049 crossrefType "journal-article" @default.
• W1497659049 hasAuthorship W1497659049A5015262464 @default.
• W1497659049 hasAuthorship W1497659049A5020071691 @default.
• W1497659049 hasAuthorship W1497659049A5035937928 @default.
• W1497659049 hasAuthorship W1497659049A5056681640 @default.
• W1497659049 hasAuthorship W1497659049A5090769439 @default.
• W1497659049 hasBestOaLocation W14976590491 @default.
• W1497659049 hasConcept C104317684 @default.
• W1497659049 hasConcept C126322002 @default.
• W1497659049 hasConcept C134459356 @default.
• W1497659049 hasConcept C139447449 @default.
• W1497659049 hasConcept C158617107 @default.
• W1497659049 hasConcept C158619295 @default.
• W1497659049 hasConcept C173396325 @default.
• W1497659049 hasConcept C190283241 @default.
• W1497659049 hasConcept C198451711 @default.
• W1497659049 hasConcept C203014093 @default.
• W1497659049 hasConcept C25602115 @default.
• W1497659049 hasConcept C2777077863 @default.
• W1497659049 hasConcept C2777575956 @default.
• W1497659049 hasConcept C502942594 @default.
• W1497659049 hasConcept C54355233 @default.
• W1497659049 hasConcept C71924100 @default.
• W1497659049 hasConcept C86803240 @default.
• W1497659049 hasConcept C95444343 @default.
• W1497659049 hasConceptScore W1497659049C104317684 @default.
• W1497659049 hasConceptScore W1497659049C126322002 @default.
• W1497659049 hasConceptScore W1497659049C134459356 @default.
• W1497659049 hasConceptScore W1497659049C139447449 @default.

• next