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• W1497659461 abstract "The extraordinary phenotypic specialization of most neuronal populations contrasts with the heterogeneity and diversity of the small sensory ganglion cells emitting thin, principally unmyelinated, axons. Electrophysiological analysis of the sense organs (receptors) associated with these axons has emphasized the properties of sensitization and polymodality—features lacking in other sense organs. Morphological analyses have revealed that although almost half the ganglion cells belong to the small neurons with C fibers, their distribution and density in the various non-integumentary regions of the body is, at best, rarely related to sensory activity. The variety of axon terminal fine structure, the classes of molecular markers for unmyelinated axons and their distinctive relations to terminal distribution patterns, and the variety of chemical stimuli now known to generate or sensitize afferent impulse activity, suggest the need for a new taxonomy of C fibers. The morphological features of contemporary painful neuropathy models in relation to cytokines, neurotrophins, and other molecular mediators of C fiber excitability changes provide the key insights into the nature of pain pathology of peripheral origin." @default.
• W1497659461 created "2016-06-24" @default.
• W1497659461 creator A5005390808 @default.
• W1497659461 date "1996-01-01" @default.
• W1497659461 modified "2023-09-27" @default.
• W1497659461 title "Chapter 16. The functional morphology of thin sensory axons: some principles and problems" @default.
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• W1497659461 doi "https://doi.org/10.1016/s0079-6123(08)61093-6" @default.
• W1497659461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9009740" @default.
• W1497659461 hasPublicationYear "1996" @default.
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