FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497677948> ?p ?o ?g. }

• W1497677948 endingPage "143" @default.
• W1497677948 startingPage "129" @default.
• W1497677948 abstract "Down syndrome DS is a genetic pathology characterized by brain hypotrophy and severe cognitive impairment. Although defective neurogenesis is an important determinant of mental disability, a severe dendritic pathology appears to be an equally important factor. A previous study showed that fluoxetine, a selective serotonin reuptake inhibitor, fully restores neurogenesis in the Ts65Dn mouse model of DS. The goal of the current study was to establish whether fluoxetine also restores dendritic development. In mice aged 45 days, treated with fluoxetine in the postnatal period P3-P15, we examined the dendritic arbor of the granule cells of the dentate gyrus (DG). The granule cells of trisomic mice had a severely hypotrophic dendritic arbor, fewer spines and a reduced innervation than euploid mice. Treatment with fluoxetine fully restored all these defects. In Ts65Dn mice, we found reduced levels of serotonin that were restored by treatment. Results show that a pharmacotherapy with fluoxetine is able to rescue not only the number of granule neurons but also their quality in terms of correct maturation and connectivity. These findings strongly suggest that fluoxetine may be a drug of choice for the improvement of the major defects in the DS brain and, possibly, of mental retardation." @default.
• W1497677948 created "2016-06-24" @default.
• W1497677948 creator A5007568958 @default.
• W1497677948 creator A5023384307 @default.
• W1497677948 creator A5032035149 @default.
• W1497677948 creator A5047891710 @default.
• W1497677948 creator A5049982074 @default.
• W1497677948 creator A5053575760 @default.
• W1497677948 creator A5056623905 @default.
• W1497677948 creator A5059950231 @default.
• W1497677948 creator A5067415184 @default.
• W1497677948 creator A5072602083 @default.
• W1497677948 date "2012-09-03" @default.
• W1497677948 modified "2023-10-01" @default.
• W1497677948 title "Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome" @default.
• W1497677948 cites W106629436 @default.
• W1497677948 cites W1820550045 @default.
• W1497677948 cites W1966023781 @default.
• W1497677948 cites W1966752348 @default.
• W1497677948 cites W1979452048 @default.
• W1497677948 cites W1986346910 @default.
• W1497677948 cites W1990003594 @default.
• W1497677948 cites W1992834359 @default.
• W1497677948 cites W1993538553 @default.
• W1497677948 cites W1995410694 @default.
• W1497677948 cites W1996154142 @default.
• W1497677948 cites W1996287373 @default.
• W1497677948 cites W2002112050 @default.
• W1497677948 cites W2002941677 @default.
• W1497677948 cites W2018733374 @default.
• W1497677948 cites W2025353122 @default.
• W1497677948 cites W2034823208 @default.
• W1497677948 cites W2041130061 @default.
• W1497677948 cites W2042551807 @default.
• W1497677948 cites W2046080106 @default.
• W1497677948 cites W2051426017 @default.
• W1497677948 cites W2058257681 @default.
• W1497677948 cites W2066368611 @default.
• W1497677948 cites W2069543713 @default.
• W1497677948 cites W2071717157 @default.
• W1497677948 cites W2074981548 @default.
• W1497677948 cites W2077110494 @default.
• W1497677948 cites W2084233122 @default.
• W1497677948 cites W2086398583 @default.
• W1497677948 cites W2089405384 @default.
• W1497677948 cites W2090544975 @default.
• W1497677948 cites W2098094095 @default.
• W1497677948 cites W2102979724 @default.
• W1497677948 cites W2118000416 @default.
• W1497677948 cites W2122209646 @default.
• W1497677948 cites W2144118821 @default.
• W1497677948 doi "https://doi.org/10.1111/j.1750-3639.2012.00624.x" @default.
• W1497677948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8028975" @default.
• W1497677948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22817700" @default.
• W1497677948 hasPublicationYear "2012" @default.
• W1497677948 type Work @default.
• W1497677948 sameAs 1497677948 @default.
• W1497677948 citedByCount "56" @default.
• W1497677948 countsByYear W14976779482013 @default.
• W1497677948 countsByYear W14976779482014 @default.
• W1497677948 countsByYear W14976779482015 @default.
• W1497677948 countsByYear W14976779482016 @default.
• W1497677948 countsByYear W14976779482017 @default.
• W1497677948 countsByYear W14976779482018 @default.
• W1497677948 countsByYear W14976779482019 @default.
• W1497677948 countsByYear W14976779482020 @default.
• W1497677948 countsByYear W14976779482021 @default.
• W1497677948 countsByYear W14976779482022 @default.
• W1497677948 countsByYear W14976779482023 @default.
• W1497677948 crossrefType "journal-article" @default.
• W1497677948 hasAuthorship W1497677948A5007568958 @default.
• W1497677948 hasAuthorship W1497677948A5023384307 @default.
• W1497677948 hasAuthorship W1497677948A5032035149 @default.
• W1497677948 hasAuthorship W1497677948A5047891710 @default.
• W1497677948 hasAuthorship W1497677948A5049982074 @default.
• W1497677948 hasAuthorship W1497677948A5053575760 @default.
• W1497677948 hasAuthorship W1497677948A5056623905 @default.
• W1497677948 hasAuthorship W1497677948A5059950231 @default.
• W1497677948 hasAuthorship W1497677948A5067415184 @default.
• W1497677948 hasAuthorship W1497677948A5072602083 @default.
• W1497677948 hasBestOaLocation W14976779482 @default.
• W1497677948 hasConcept C126322002 @default.
• W1497677948 hasConcept C148762608 @default.
• W1497677948 hasConcept C15744967 @default.
• W1497677948 hasConcept C169760540 @default.
• W1497677948 hasConcept C170493617 @default.
• W1497677948 hasConcept C174884520 @default.
• W1497677948 hasConcept C2775864247 @default.
• W1497677948 hasConcept C2776134451 @default.
• W1497677948 hasConcept C2776464000 @default.
• W1497677948 hasConcept C2780092697 @default.
• W1497677948 hasConcept C4746552 @default.
• W1497677948 hasConcept C71924100 @default.
• W1497677948 hasConceptScore W1497677948C126322002 @default.
• W1497677948 hasConceptScore W1497677948C148762608 @default.
• W1497677948 hasConceptScore W1497677948C15744967 @default.
• W1497677948 hasConceptScore W1497677948C169760540 @default.
• W1497677948 hasConceptScore W1497677948C170493617 @default.

• next