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- W1497689470 abstract "Publisher Summary Antiviral cytokines (interferons or IFNs) and chemokines activated as an early response to infection play an important role both in the outcome of the viral infection and in its virulence. Interferons can inhibit viral replication directly by inducing an antiviral state in the host cells. Indirect inhibition occurs because of increasing the expression of major histocompatibility complex (MHC) antigens, initiating inflammatory responses, and stimulating the development of cytotoxic T cells as well as the differentiation of B cells into antibody-producing plasma cells. Interferons also play a crucial role in the activation of macrophages and natural killer (NK) cells. The interferon regulatory factors (IRFs) play a critical role in the induction of Type I IFN and chemokine genes, as well as genes mediating antiviral, antibacterial, and inflammatory responses. The innate immune response develops as a rapid and regulated defense mechanism in which the recognition of an invading pathogenic organism occurs on binding to a specific cytoplasmic receptor or to a Toll-like receptor (TLR). These TLRs recognize the conserved patterns of proteins, lipoproteins, double-stranded (ds) RNA, or unmethylated CpG DNA that are pathogen-associated molecular patterns (PAMPs)." @default.
- W1497689470 created "2016-06-24" @default.
- W1497689470 creator A5039478606 @default.
- W1497689470 creator A5056299792 @default.
- W1497689470 date "2006-01-01" @default.
- W1497689470 modified "2023-09-25" @default.
- W1497689470 title "The Innate Antiviral Response: New Insights Into A Continuing Story" @default.
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