Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497692202> ?p ?o ?g. }
- W1497692202 endingPage "803" @default.
- W1497692202 startingPage "796" @default.
- W1497692202 abstract "Cerebral apolipoprotein E (apoE) has been implicated in neuronal protection and repair. Due to the variable levels and types of estrogen receptors within different brain regions, the effect of estrogen on apoE and the mechanism of this effect may vary within different regions. Ovariectomized female C57BL/6 mice were treated with pharmacological levels of 17 beta-estradiol or placebo for 5 days, resulting in supraphysiological plasma levels of estradiol in the treated mice. ApoE and glial fibrillary acidic protein (GFAP) levels were measured in the cortex, hippocampus and diencephalon. 17 beta-Estradiol up-regulated apoE but not GFAP in the cortex and diencephalon, whereas in the hippocampus, GFAP and apoE were equally up-regulated. Treatment of estrogen receptor (ER) alpha knockout mice with 17 beta-estradiol or treatment of C57BL/6 mice with 17 alpha-estradiol, a poor estrogen receptor agonist, specifically induced apoE in the cortex, but not in the diencephalon. These results indicate that 17 beta-estradiol effects on apoE are either directly or indirectly mediated by ER alpha in the diencephalon, while the effects in the cortex may be mediated by a non-classical mechanism or by ER beta. Measurement of mRNA levels in estrogen versus placebo-treated wild-type mice indicated that the effect of 17 beta-estradiol on apoE was not associated with changes in apoE mRNA levels." @default.
- W1497692202 created "2016-06-24" @default.
- W1497692202 creator A5002512182 @default.
- W1497692202 creator A5009116356 @default.
- W1497692202 creator A5035103174 @default.
- W1497692202 creator A5037771157 @default.
- W1497692202 creator A5050133254 @default.
- W1497692202 creator A5073087299 @default.
- W1497692202 date "2008-07-07" @default.
- W1497692202 modified "2023-09-23" @default.
- W1497692202 title "Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments" @default.
- W1497692202 cites W1808137900 @default.
- W1497692202 cites W1963092557 @default.
- W1497692202 cites W1963783263 @default.
- W1497692202 cites W1967863634 @default.
- W1497692202 cites W1972522896 @default.
- W1497692202 cites W1980535385 @default.
- W1497692202 cites W1984496769 @default.
- W1497692202 cites W1985859760 @default.
- W1497692202 cites W1986241901 @default.
- W1497692202 cites W1990547324 @default.
- W1497692202 cites W1996604707 @default.
- W1497692202 cites W1997913988 @default.
- W1497692202 cites W1998443184 @default.
- W1497692202 cites W2003527151 @default.
- W1497692202 cites W2004584009 @default.
- W1497692202 cites W2009068939 @default.
- W1497692202 cites W2017212398 @default.
- W1497692202 cites W2019455802 @default.
- W1497692202 cites W2021449355 @default.
- W1497692202 cites W2030933570 @default.
- W1497692202 cites W2031918005 @default.
- W1497692202 cites W2032679733 @default.
- W1497692202 cites W2035883738 @default.
- W1497692202 cites W2040792002 @default.
- W1497692202 cites W2041840560 @default.
- W1497692202 cites W2050581082 @default.
- W1497692202 cites W2051055551 @default.
- W1497692202 cites W2054110130 @default.
- W1497692202 cites W2055705342 @default.
- W1497692202 cites W2056371795 @default.
- W1497692202 cites W2058222310 @default.
- W1497692202 cites W2059819603 @default.
- W1497692202 cites W2061571075 @default.
- W1497692202 cites W2061800243 @default.
- W1497692202 cites W2068189478 @default.
- W1497692202 cites W2071486760 @default.
- W1497692202 cites W2073883348 @default.
- W1497692202 cites W2075564085 @default.
- W1497692202 cites W2084703128 @default.
- W1497692202 cites W2088347760 @default.
- W1497692202 cites W2109137609 @default.
- W1497692202 cites W2111398489 @default.
- W1497692202 cites W2115309238 @default.
- W1497692202 cites W2127129379 @default.
- W1497692202 cites W2136249808 @default.
- W1497692202 cites W2141269411 @default.
- W1497692202 cites W2145865543 @default.
- W1497692202 cites W2155406256 @default.
- W1497692202 cites W2158773633 @default.
- W1497692202 cites W2165807863 @default.
- W1497692202 cites W4233906629 @default.
- W1497692202 cites W4322388716 @default.
- W1497692202 doi "https://doi.org/10.1046/j.1471-4159.2001.00627.x" @default.
- W1497692202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11723172" @default.
- W1497692202 hasPublicationYear "2008" @default.
- W1497692202 type Work @default.
- W1497692202 sameAs 1497692202 @default.
- W1497692202 citedByCount "53" @default.
- W1497692202 countsByYear W14976922022012 @default.
- W1497692202 countsByYear W14976922022013 @default.
- W1497692202 countsByYear W14976922022014 @default.
- W1497692202 countsByYear W14976922022015 @default.
- W1497692202 countsByYear W14976922022016 @default.
- W1497692202 countsByYear W14976922022018 @default.
- W1497692202 countsByYear W14976922022019 @default.
- W1497692202 countsByYear W14976922022020 @default.
- W1497692202 crossrefType "journal-article" @default.
- W1497692202 hasAuthorship W1497692202A5002512182 @default.
- W1497692202 hasAuthorship W1497692202A5009116356 @default.
- W1497692202 hasAuthorship W1497692202A5035103174 @default.
- W1497692202 hasAuthorship W1497692202A5037771157 @default.
- W1497692202 hasAuthorship W1497692202A5050133254 @default.
- W1497692202 hasAuthorship W1497692202A5073087299 @default.
- W1497692202 hasConcept C121608353 @default.
- W1497692202 hasConcept C126322002 @default.
- W1497692202 hasConcept C134018914 @default.
- W1497692202 hasConcept C170493617 @default.
- W1497692202 hasConcept C2775969318 @default.
- W1497692202 hasConcept C2777003273 @default.
- W1497692202 hasConcept C2777164284 @default.
- W1497692202 hasConcept C2778938600 @default.
- W1497692202 hasConcept C2779134260 @default.
- W1497692202 hasConcept C2781041448 @default.
- W1497692202 hasConcept C2781161787 @default.
- W1497692202 hasConcept C530470458 @default.
- W1497692202 hasConcept C57089818 @default.
- W1497692202 hasConcept C71924100 @default.