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- W1497694473 abstract "A number of solvents, including dimethylsulfoxide (DMSO), when substituted for acetone as the vehicle for the potent promoter phorbol-12-myristate-13-acetate (PMA) in the two-stage mouse skin cancer model, tend to inhibit tumorigenesis. DMSO was investigated further because the literature is ambiguous concerning its effect in both single and multi-stage carcinogenesis. As solvent for the complete carcinogen benzo(a)pyrene (BaP, 125 mg in 40 ..mu..l 2x/wk), tumor yield increased an avg of 245% (3 trials in C3H mice) compared to acetone/BaP. However, in the two-stage model (CD-1 mice initiated with 50-100 ..mu..g DMBA) DMSO as the vehicle for PMA (5 ..mu..g in 40 ..mu..l 2x/wk) reduced tumor yield to 34% of the PMA/acetone controls. To test whether the inhibition was an in vitro effect, 40 ..mu..l DMSO was applied at the initiation site, the back, up to one hr before PMA/acetone. In three trials tumor yield averaged 23% of controls. To determine whether the DMSO effect was directly on initiated cells or indirectly via the systemic circulation, 40 ..mu..l DMSO was applied prior to promotion at a site distant from initiation/promotion, the abdomen. In three trials, DMSO enhanced tumor yield by 194%. DMSO itself had no initiating or promotion effects. Thus, it appearsmore » that DMSO may either inhibit or enhance mouse skin tumorigenesis depending on its method of application.« less" @default.
- W1497694473 created "2016-06-24" @default.
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- W1497694473 date "1986-03-05" @default.
- W1497694473 modified "2023-09-26" @default.
- W1497694473 title "Conflicting effects of DMSO on mouse skin tumorigenesis" @default.
- W1497694473 hasPublicationYear "1986" @default.
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