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- W1497695171 abstract "Summary. Primary or secondary failure of adefovir dipivoxil (ADV) therapy of chronic hepatitis B is not infrequent. The reasons for suboptimal responses are not well defined. In HIV and hepatitis C virus infection, failure of antiviral drug therapy has been linked with low blood drug levels. We have studied 20 well‐defined patients with chronic hepatitis B who were treated with ADV for drug and virus kinetics. Importantly, neither Cmax levels (mean 26 ng/mL, range 14–59 ng/mL) nor the time to maximal drug levels (mean 4 h, range 2–8 h) differed between patients showing a complete virological response to adefovir ( n = 10), patients with secondary treatment failure ( n = 7) and patients with suboptimal primary response (hepatitis B virus‐DNA >10 000 IU/mL after 6 months of treatment; n = 3). Thus, adefovir treatment failure is unlikely to be due to an inability to mount sufficient drug levels in the blood." @default.
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- W1497695171 date "2011-01-07" @default.
- W1497695171 modified "2023-09-26" @default.
- W1497695171 title "Adefovir serum levels do not differ between responders and nonresponders" @default.
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- W1497695171 doi "https://doi.org/10.1111/j.1365-2893.2010.01404.x" @default.
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