Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497697383> ?p ?o ?g. }
- W1497697383 endingPage "1358" @default.
- W1497697383 startingPage "1350" @default.
- W1497697383 abstract "The phospholipase C (PLC) pathway is the major signaling mechanism of photoactivation in invertebrate photoreceptors. Here we report the cloning of a cDNA encoding a 140-kDa retinal PLC that is uniquely expressed in squid photoreceptors. This cDNA encodes a protein with multiple distinct modular domains: PH, X and Y catalytic, and C2 domains, as well as G- and P-box motifs and two GTP/ATP binding motifs. The PLC was stimulated by activated squid Gqα but not by squid Gqβγ or mammalian βγ subunits. The PLC was inhibited by monophosphate, diphosphate and triphosphate nucleotides but not cyclic nucleosides. We also tested the ability of PLC-140 to regulate the GTPase activity of Gqα in the rhabdomeric membranes. Depletion of PLC-140 from the rhabdomeric membranes decreased the GTP hydrolysis but not GTPγS binding to the membranes. Reconstitution of purified PLC-140 with membranes accelerated Gqα GTPase activity by fivefold at a concentration of 2.5 µm. Our data suggest that PLC-140 plays an important role in both the activation and inactivation pathways of invertebrate visual transduction." @default.
- W1497697383 created "2016-06-24" @default.
- W1497697383 creator A5044660945 @default.
- W1497697383 creator A5060430551 @default.
- W1497697383 creator A5065344260 @default.
- W1497697383 date "2001-12-20" @default.
- W1497697383 modified "2023-10-18" @default.
- W1497697383 title "Retinal phospholipase C from squid is a regulator of Gqα GTPase activity" @default.
- W1497697383 cites W1490293082 @default.
- W1497697383 cites W1497665885 @default.
- W1497697383 cites W1502744256 @default.
- W1497697383 cites W1544613378 @default.
- W1497697383 cites W1549118234 @default.
- W1497697383 cites W1568965788 @default.
- W1497697383 cites W1583005424 @default.
- W1497697383 cites W1599140803 @default.
- W1497697383 cites W1600300278 @default.
- W1497697383 cites W1606090338 @default.
- W1497697383 cites W1667251229 @default.
- W1497697383 cites W1669965315 @default.
- W1497697383 cites W1884928912 @default.
- W1497697383 cites W1968352234 @default.
- W1497697383 cites W1969420596 @default.
- W1497697383 cites W1969722894 @default.
- W1497697383 cites W1976801496 @default.
- W1497697383 cites W1977390983 @default.
- W1497697383 cites W1977598234 @default.
- W1497697383 cites W1983439901 @default.
- W1497697383 cites W1987718946 @default.
- W1497697383 cites W2006455216 @default.
- W1497697383 cites W2010601153 @default.
- W1497697383 cites W2026390924 @default.
- W1497697383 cites W2029078879 @default.
- W1497697383 cites W2033091999 @default.
- W1497697383 cites W2038612592 @default.
- W1497697383 cites W2050923205 @default.
- W1497697383 cites W2051025707 @default.
- W1497697383 cites W2053520635 @default.
- W1497697383 cites W2058151437 @default.
- W1497697383 cites W2070310331 @default.
- W1497697383 cites W2073579032 @default.
- W1497697383 cites W2078495945 @default.
- W1497697383 cites W2092842984 @default.
- W1497697383 cites W2096549360 @default.
- W1497697383 cites W2100837269 @default.
- W1497697383 cites W2101108802 @default.
- W1497697383 cites W2102424043 @default.
- W1497697383 cites W2104319274 @default.
- W1497697383 cites W2118656164 @default.
- W1497697383 cites W2150691484 @default.
- W1497697383 cites W2166100212 @default.
- W1497697383 cites W2916193864 @default.
- W1497697383 cites W33975413 @default.
- W1497697383 cites W4235967964 @default.
- W1497697383 doi "https://doi.org/10.1046/j.1471-4159.2001.00519.x" @default.
- W1497697383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11579143" @default.
- W1497697383 hasPublicationYear "2001" @default.
- W1497697383 type Work @default.
- W1497697383 sameAs 1497697383 @default.
- W1497697383 citedByCount "11" @default.
- W1497697383 countsByYear W14976973832013 @default.
- W1497697383 countsByYear W14976973832015 @default.
- W1497697383 countsByYear W14976973832019 @default.
- W1497697383 crossrefType "journal-article" @default.
- W1497697383 hasAuthorship W1497697383A5044660945 @default.
- W1497697383 hasAuthorship W1497697383A5060430551 @default.
- W1497697383 hasAuthorship W1497697383A5065344260 @default.
- W1497697383 hasConcept C118716 @default.
- W1497697383 hasConcept C131667965 @default.
- W1497697383 hasConcept C181199279 @default.
- W1497697383 hasConcept C207332259 @default.
- W1497697383 hasConcept C2776638253 @default.
- W1497697383 hasConcept C2778597717 @default.
- W1497697383 hasConcept C2780827179 @default.
- W1497697383 hasConcept C55493867 @default.
- W1497697383 hasConcept C62478195 @default.
- W1497697383 hasConcept C66135807 @default.
- W1497697383 hasConcept C80631254 @default.
- W1497697383 hasConcept C86803240 @default.
- W1497697383 hasConcept C95444343 @default.
- W1497697383 hasConceptScore W1497697383C118716 @default.
- W1497697383 hasConceptScore W1497697383C131667965 @default.
- W1497697383 hasConceptScore W1497697383C181199279 @default.
- W1497697383 hasConceptScore W1497697383C207332259 @default.
- W1497697383 hasConceptScore W1497697383C2776638253 @default.
- W1497697383 hasConceptScore W1497697383C2778597717 @default.
- W1497697383 hasConceptScore W1497697383C2780827179 @default.
- W1497697383 hasConceptScore W1497697383C55493867 @default.
- W1497697383 hasConceptScore W1497697383C62478195 @default.
- W1497697383 hasConceptScore W1497697383C66135807 @default.
- W1497697383 hasConceptScore W1497697383C80631254 @default.
- W1497697383 hasConceptScore W1497697383C86803240 @default.
- W1497697383 hasConceptScore W1497697383C95444343 @default.
- W1497697383 hasIssue "6" @default.
- W1497697383 hasLocation W14976973831 @default.
- W1497697383 hasLocation W14976973832 @default.
- W1497697383 hasOpenAccess W1497697383 @default.
- W1497697383 hasPrimaryLocation W14976973831 @default.