Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497804060> ?p ?o ?g. }
- W1497804060 endingPage "8935" @default.
- W1497804060 startingPage "8932" @default.
- W1497804060 abstract "Mitochondrial ferredoxins mediate electron transfer from NADPH:ferredoxin oxidoreductase to cytochrome P450 enzymes. Previous studies on human ferredoxin, in which acidic residues were replaced with neutral amino acids, established that Asp-76 and Asp-79 are are important for binding to both reductase and P450 (Coghlan, V. M., and Vickery, L. E. (1991) J. Biol. Chem. 266, 18606-18612). Here we report that replacement of Asp----Glu at position 76 or 79, whereas maintaining negative charge at these positions also results in dramatic decreases in binding affinity for both electron transfer partners (5-100-fold, delta(delta G) approximately 1.0-2.8 kcal/mol). These results imply that the active electron transfer in these systems are dominated by a stable form which requires specific pairwise electrostatic interactions of fixed geometry for recognition and binding. This mechanism contrasts with that proposed for other electron transfer systems (as exemplified by cytochrome c) in which electrostatic interactions are believed to function primarily in precollisional orientation leading to encounter complexes having multiple geometries of similar free energy." @default.
- W1497804060 created "2016-06-24" @default.
- W1497804060 creator A5035012991 @default.
- W1497804060 creator A5057058961 @default.
- W1497804060 date "1992-05-01" @default.
- W1497804060 modified "2023-10-03" @default.
- W1497804060 title "Electrostatic interactions stabilizing ferredoxin electron transfer complexes. Disruption by “conservative” mutations." @default.
- W1497804060 cites W1497485906 @default.
- W1497804060 cites W1499452131 @default.
- W1497804060 cites W1503626128 @default.
- W1497804060 cites W1510504626 @default.
- W1497804060 cites W1523760158 @default.
- W1497804060 cites W1526151739 @default.
- W1497804060 cites W1532212858 @default.
- W1497804060 cites W1536166459 @default.
- W1497804060 cites W1545046786 @default.
- W1497804060 cites W1548277630 @default.
- W1497804060 cites W1594429603 @default.
- W1497804060 cites W1600839384 @default.
- W1497804060 cites W1603832006 @default.
- W1497804060 cites W1991078253 @default.
- W1497804060 cites W1991958052 @default.
- W1497804060 cites W2001309548 @default.
- W1497804060 cites W2003065309 @default.
- W1497804060 cites W2006975013 @default.
- W1497804060 cites W2009463385 @default.
- W1497804060 cites W2020290901 @default.
- W1497804060 cites W2027560826 @default.
- W1497804060 cites W2029779827 @default.
- W1497804060 cites W2029930123 @default.
- W1497804060 cites W2035121582 @default.
- W1497804060 cites W2036402126 @default.
- W1497804060 cites W204131078 @default.
- W1497804060 cites W2048029310 @default.
- W1497804060 cites W2055724834 @default.
- W1497804060 cites W2056869347 @default.
- W1497804060 cites W2062223607 @default.
- W1497804060 cites W2064149761 @default.
- W1497804060 cites W2068490929 @default.
- W1497804060 cites W2081082999 @default.
- W1497804060 cites W2083908721 @default.
- W1497804060 cites W2086176815 @default.
- W1497804060 cites W2109482230 @default.
- W1497804060 cites W2404798282 @default.
- W1497804060 doi "https://doi.org/10.1016/s0021-9258(19)50369-6" @default.
- W1497804060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1349603" @default.
- W1497804060 hasPublicationYear "1992" @default.
- W1497804060 type Work @default.
- W1497804060 sameAs 1497804060 @default.
- W1497804060 citedByCount "62" @default.
- W1497804060 countsByYear W14978040602018 @default.
- W1497804060 countsByYear W14978040602019 @default.
- W1497804060 countsByYear W14978040602022 @default.
- W1497804060 crossrefType "journal-article" @default.
- W1497804060 hasAuthorship W1497804060A5035012991 @default.
- W1497804060 hasAuthorship W1497804060A5057058961 @default.
- W1497804060 hasBestOaLocation W14978040601 @default.
- W1497804060 hasConcept C121332964 @default.
- W1497804060 hasConcept C123669783 @default.
- W1497804060 hasConcept C12554922 @default.
- W1497804060 hasConcept C134621786 @default.
- W1497804060 hasConcept C147120987 @default.
- W1497804060 hasConcept C159467904 @default.
- W1497804060 hasConcept C181199279 @default.
- W1497804060 hasConcept C185592680 @default.
- W1497804060 hasConcept C24840226 @default.
- W1497804060 hasConcept C55493867 @default.
- W1497804060 hasConcept C62520636 @default.
- W1497804060 hasConcept C75473681 @default.
- W1497804060 hasConcept C86803240 @default.
- W1497804060 hasConceptScore W1497804060C121332964 @default.
- W1497804060 hasConceptScore W1497804060C123669783 @default.
- W1497804060 hasConceptScore W1497804060C12554922 @default.
- W1497804060 hasConceptScore W1497804060C134621786 @default.
- W1497804060 hasConceptScore W1497804060C147120987 @default.
- W1497804060 hasConceptScore W1497804060C159467904 @default.
- W1497804060 hasConceptScore W1497804060C181199279 @default.
- W1497804060 hasConceptScore W1497804060C185592680 @default.
- W1497804060 hasConceptScore W1497804060C24840226 @default.
- W1497804060 hasConceptScore W1497804060C55493867 @default.
- W1497804060 hasConceptScore W1497804060C62520636 @default.
- W1497804060 hasConceptScore W1497804060C75473681 @default.
- W1497804060 hasConceptScore W1497804060C86803240 @default.
- W1497804060 hasIssue "13" @default.
- W1497804060 hasLocation W14978040601 @default.
- W1497804060 hasOpenAccess W1497804060 @default.
- W1497804060 hasPrimaryLocation W14978040601 @default.
- W1497804060 hasRelatedWork W1745869941 @default.
- W1497804060 hasRelatedWork W1980593250 @default.
- W1497804060 hasRelatedWork W2009852647 @default.
- W1497804060 hasRelatedWork W2045956441 @default.
- W1497804060 hasRelatedWork W2070730177 @default.
- W1497804060 hasRelatedWork W2080722522 @default.
- W1497804060 hasRelatedWork W2108891893 @default.
- W1497804060 hasRelatedWork W2317858593 @default.
- W1497804060 hasRelatedWork W2474928405 @default.
- W1497804060 hasRelatedWork W47391677 @default.
- W1497804060 hasVolume "267" @default.