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- W1497804286 abstract "The term antimicrobial can be used to define any compound that exhibits an inhibition of fungal or bacterial growth. There are many plant peptides that possess strong activity in vitro against plant-pathogenic fungi, of which the antifungal peptides (AFPs) belong to a group of antimicrobial peptides (AMPs) referred to as “disulfide-linked peptides.” These peptides are approximately 50 amino acids in length and contain cysteine residues that allow for the formation of disulfide bonds. These internal disulfide bridges dictate the conformation of the molecules for biological activity. All plant AMPs that have been isolated and characterized to date have even (4, 6, or 8) numbers of cysteines connected by disulfide bridges contributing to their high stability. Plant defensins are peptides that are inhibitory to phytopathogenic filamentous fungi, such as A. brassicola , A. longipes , C. beticola , F. culmorum , L. maculans , N. crassa , P. tritici-repentis , P. oryzae , and several bacterial pathogens of plants. The ability of plant defensins to control fungal pathogens in planta has been studied by generating transgenic plants carrying chimeric gene constructs. Transgenic tobacco plants carrying the Mj-AMP2 gene show increased resistance to plant pathogens. To study the processing, sorting, and biological activity of this peptide, two different gene constructs, a wild-type and a vacuolar targeting signal sequence mutant Mj-AMP2 in tobacco plants, were constructed. Analysis of the transgenic plants for processing and localization of these peptides indicated that plants transformed with the wild-type and the mutant constructs respectively accumulate Mj-AMP2, extracellularly and intracellularly." @default.
- W1497804286 created "2016-06-24" @default.
- W1497804286 creator A5002836935 @default.
- W1497804286 creator A5013485778 @default.
- W1497804286 date "2001-01-01" @default.
- W1497804286 modified "2023-09-24" @default.
- W1497804286 title "Plant antifungal peptides and their use in transgenic food crops" @default.
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