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• W1497808863 abstract "Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs." @default.
• W1497808863 created "2016-06-24" @default.
• W1497808863 creator A5008748795 @default.
• W1497808863 creator A5082258015 @default.
• W1497808863 date "2016-01-01" @default.
• W1497808863 modified "2023-09-23" @default.
• W1497808863 title "Long Noncoding RNA Regulation of Pluripotency" @default.
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• W1497808863 doi "https://doi.org/10.1155/2016/1797692" @default.
• W1497808863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4677244" @default.
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• W1497808863 hasPublicationYear "2016" @default.
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