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- W1497809959 abstract "High blood concentration of low-density lipoprotein (LDL) cholesterol is a major risk factor for early development of atherosclerosis. Massive accumulation of cholesterol in the arterial wall and formation of lipid-laden cells (foam cells) typical of the atheromatous plaque occur after LDL entrapment in the subendothelial space. However, there is a general agreement that native non-modified LDL does not present any of the typical features of an atherogenic lipoprotein; native LDL does not promote foam cell formation and has no inflammatory, proliferative or apoptotic capacity. It is therefore assumed that when LDL is trapped in the arterial wall it is modified by several mechanisms such as lipoperoxidation, non-enzymatic glycosylation, enzymatic lipolysis and/or proteolysis. As a consequence, modified LDL particles acquire inflammatory and apoptotic capacity and are recognizable by scavenger receptors to promote foam cell formation. Although most studies on LDL modification have focused on mechanisms that could occur in the vessel wall, modified LDL particles have been reported in blood. The concentration of these particles is increased in subjects with high cardiovascular risk. The present chapter reviews the possible mechanisms leading to LDL modification. It then focuses on a subfraction of modified LDL particles detected in plasma, named electronegative LDL." @default.
- W1497809959 created "2016-06-24" @default.
- W1497809959 creator A5037240373 @default.
- W1497809959 creator A5056197299 @default.
- W1497809959 date "2012-01-11" @default.
- W1497809959 modified "2023-10-01" @default.
- W1497809959 title "Modified Forms of LDL in Plasma" @default.
- W1497809959 cites W1584774790 @default.
- W1497809959 cites W1853133898 @default.
- W1497809959 cites W1857052429 @default.
- W1497809959 cites W1865909644 @default.
- W1497809959 cites W1878021016 @default.
- W1497809959 cites W1879201657 @default.
- W1497809959 cites W1966268806 @default.
- W1497809959 cites W1971123289 @default.
- W1497809959 cites W1975479080 @default.
- W1497809959 cites W1975770362 @default.
- W1497809959 cites W1975856506 @default.
- W1497809959 cites W1977619203 @default.
- W1497809959 cites W1977887801 @default.
- W1497809959 cites W1978488814 @default.
- W1497809959 cites W1979675507 @default.
- W1497809959 cites W1981117358 @default.
- W1497809959 cites W1982638309 @default.
- W1497809959 cites W1985818067 @default.
- W1497809959 cites W198746106 @default.
- W1497809959 cites W1991223330 @default.
- W1497809959 cites W1993077610 @default.
- W1497809959 cites W1994395391 @default.
- W1497809959 cites W1995326030 @default.
- W1497809959 cites W1995617096 @default.
- W1497809959 cites W1998989384 @default.
- W1497809959 cites W1999277192 @default.
- W1497809959 cites W2002602976 @default.
- W1497809959 cites W2004046585 @default.
- W1497809959 cites W2008416260 @default.
- W1497809959 cites W2008633316 @default.
- W1497809959 cites W2009624999 @default.
- W1497809959 cites W2014117331 @default.
- W1497809959 cites W2014794502 @default.
- W1497809959 cites W2018622490 @default.
- W1497809959 cites W2020185822 @default.
- W1497809959 cites W2021278775 @default.
- W1497809959 cites W2021937355 @default.
- W1497809959 cites W2022016683 @default.
- W1497809959 cites W2024059969 @default.
- W1497809959 cites W2024574408 @default.
- W1497809959 cites W2027774630 @default.
- W1497809959 cites W2028992794 @default.
- W1497809959 cites W2030029464 @default.
- W1497809959 cites W2032588474 @default.
- W1497809959 cites W2034400876 @default.
- W1497809959 cites W2037019145 @default.
- W1497809959 cites W2038610374 @default.
- W1497809959 cites W2038890840 @default.
- W1497809959 cites W2039593108 @default.
- W1497809959 cites W2040374028 @default.
- W1497809959 cites W2040579726 @default.
- W1497809959 cites W2041221827 @default.
- W1497809959 cites W2042482256 @default.
- W1497809959 cites W2043670503 @default.
- W1497809959 cites W2045332651 @default.
- W1497809959 cites W2045624939 @default.
- W1497809959 cites W2045868118 @default.
- W1497809959 cites W2046755317 @default.
- W1497809959 cites W2047643718 @default.
- W1497809959 cites W2049098647 @default.
- W1497809959 cites W2049401036 @default.
- W1497809959 cites W2049444075 @default.
- W1497809959 cites W2049761740 @default.
- W1497809959 cites W2050512116 @default.
- W1497809959 cites W2051165964 @default.
- W1497809959 cites W2052130065 @default.
- W1497809959 cites W2053071472 @default.
- W1497809959 cites W2053852100 @default.
- W1497809959 cites W2055412588 @default.
- W1497809959 cites W2056237978 @default.
- W1497809959 cites W2057359092 @default.
- W1497809959 cites W2057895074 @default.
- W1497809959 cites W2059592018 @default.
- W1497809959 cites W2059656707 @default.
- W1497809959 cites W2060256649 @default.
- W1497809959 cites W2064179373 @default.
- W1497809959 cites W2064653649 @default.
- W1497809959 cites W2066343714 @default.
- W1497809959 cites W2069401919 @default.
- W1497809959 cites W2069537563 @default.
- W1497809959 cites W2069870017 @default.
- W1497809959 cites W2070951814 @default.
- W1497809959 cites W2074309433 @default.
- W1497809959 cites W2074891571 @default.
- W1497809959 cites W2078339080 @default.
- W1497809959 cites W2079571676 @default.
- W1497809959 cites W2079957606 @default.
- W1497809959 cites W2081437358 @default.
- W1497809959 cites W2081922902 @default.
- W1497809959 cites W2083976132 @default.
- W1497809959 cites W2084398875 @default.
- W1497809959 cites W2084439619 @default.
- W1497809959 cites W2084744450 @default.