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• W1497858682 abstract "To cite this article: Roth N, Städler S, Lemann M, Hösli S, Simon H‐U, Simon D. Distinct eosinophil cytokine expression patterns in skin diseases – the possible existence of functionally different eosinophil subpopulations. Allergy 2011; 66 : 1477–1486. Abstract Background: The function of eosinophils has been attributed to host defense, immunomodulation, and fibrosis. Although eosinophils are found among infiltrating cells in a broad spectrum of skin diseases, their pathogenic role remains uncertain. This study aimed to analyze the cytokine expression by eosinophils in different skin diseases. Methods: Skin specimens from different skin diseases [allergic/reactive, infectious, autoimmune, and tumors/lymphomas (LY)] were stained by antibodies directed to eosinophil cationic protein, cytokines [tumor necrosis factor (TNF)‐α, interleukin (IL)‐5, IL‐6, IL‐10, IL‐11, IL‐13, IL‐17, IL‐25, IL‐33, interferon‐γ, transforming growth factor (TGF)‐β, and thymic stromal lymphopoietin], eotaxins (CCL11, CCL24, and CCL26), metalloproteinase (MMP)‐9 as well as extracellular matrix proteins (tenascin‐C and procollagen‐3) and then analyzed by laser scanning microscopy. Results: The number of eosinophils varied considerably in and between disease groups and did not correlate with the numbers of accompanying inflammatory cells. The expression of IL‐5, IL‐6, IL‐11, TGF‐β, CCL24, and MMP‐9 by eosinophils significantly differed between disease groups. Eosinophils in tumors/LY predominantly expressed IL‐6, TGF‐β, and CCL24, but not IL‐11. On the other hand, in autoimmune diseases, eosinophils largely contributed to MMP‐9 production. IL‐5‐generating eosinophils were particularly obvious in allergic and infectious diseases. Conclusion: In skin diseases, eosinophil expresses a broad spectrum of cytokines. The different cytokine expression patterns suggest distinct functional roles of eosinophils in these diseases that might be related to host defense, immunomodulation, fibrosis, and/or tumor development." @default.
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• W1497858682 date "2011-09-02" @default.
• W1497858682 modified "2023-10-17" @default.
• W1497858682 title "Distinct eosinophil cytokine expression patterns in skin diseases - the possible existence of functionally different eosinophil subpopulations" @default.
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• W1497858682 doi "https://doi.org/10.1111/j.1398-9995.2011.02694.x" @default.
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