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- W1498049321 endingPage "167" @default.
- W1498049321 startingPage "122" @default.
- W1498049321 abstract "The first section of this chapter details current, marketed pharmacological treatments for Alzheimer’s disease, the extent of efficacy, adverse effects, and the controversies surrounding their use, including when to treat, for how long, expected effects, and long-term adversity. The second part overviews the rationale, development, and results of current prevention trials, all with marketed compounds, and their implications for planning future prevention trials. The third part assesses current therapy development, including drugs in phase 1, 2, and 3 clinical trials, their potential activity or inactivity, challenges of developing new treatments, including challenges of the clinical development programs, clinical trials design, and the role of proposed new diagnostic criteria in clinical trial design. Some drugs recently and currently in development are reviewed, their limitations and challenges, and what it means from a research perspective when a drug fails clinical trials. Overall, there are considerable challenges to Alzheimer’s disease therapeutics as the marketed drugs, although helpful for some patients, show only small clinical effects over the short term and a degree of unappreciated toxicity over the longer term. There has not been a new drug in over a decade; drug development programs aimed at new targets have been unsuccessful thus far even though they are designed to detect small effects from the new drugs. There is nevertheless basis for considerable optimism that effective interventions soon will be found." @default.
- W1498049321 created "2016-06-24" @default.
- W1498049321 creator A5059020389 @default.
- W1498049321 date "2012-01-01" @default.
- W1498049321 modified "2023-10-02" @default.
- W1498049321 title "Pharmacological Treatment of Alzheimer’s Disease" @default.
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