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• W1498078395 abstract "Abstract Aim: To evaluate the efficacy of a 2‐week administration of a 0.1% chlorhexidine mouthwash in the short‐term treatment of chronic periodontitis patients and the impact of this product when administered twice by pocket irrigation. Methods: Sixty patients were enrolled in a single‐centre, placebo‐controlled, randomized study with the blind allocation of product to two parallel groups. Clinical assessments were performed, and samples from six selected subgingival sites were collected for microbial analysis by culture at baseline, D15 and D56. Three of the six sites were randomly selected and were treated by subgingival irrigation with the same 0.1% chlorhexidine product at D0 and D7. A subsequent statistical analysis was performed using the paired Student’s t ‐test and Wilcoxon rank sum test for within‐group analyses; analysis of variance and the Kruskall–Wallis test were used for between‐group analyses. Results: Two‐week treatment with a 0.1% chlorhexidine mouthwash slightly reduced the gingival inflammation associated with periodontitis. We observed a significant decrease in Gram‐negative, facultative anaerobes and micro‐aerophiles, and a significant increase in Gram‐positive cocci. No increase in the treatment effect was demonstrated by irrigation of the periodontal pockets. Conclusion: The 0.1% chlorhexidine mouthwash showed limited beneficial effects in the treatment of periodontitis patients." @default.
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• W1498078395 date "2010-11-08" @default.
• W1498078395 modified "2023-10-17" @default.
• W1498078395 title "An 8-week, randomized, controlled, clinical study of the use of a 0.1% chlorhexidine mouthwash by chronic periodontitis patients" @default.
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• W1498078395 doi "https://doi.org/10.1111/j.2041-1626.2010.00031.x" @default.
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