FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498102997> ?p ?o ?g. }

• W1498102997 endingPage "24395" @default.
• W1498102997 startingPage "24391" @default.
• W1498102997 abstract "Cytokines and growth factors elicit responses in target cells through induction of gene expression. Signaling mechanisms leading to gene transcription from cell surface receptors often require tyrosine phosphorylation. A family of transcription factors comprising the interferon (IFN)-stimulated gene factor 3 (ISGF3) multimeric complex are phosphorylated and activated in response to interferon. We describe a protein 50% identical to the 91-kDa subunit of ISGF3 that constitutes the acute phase response factor (APRF). This protein was rapidly activated by interleukin-6 to bind an enhancer element common to genes activated in liver cells during the acute phase response to inflammation. Remarkably, APRF was also activated by IFN alpha, IFN gamma, epidermal growth factor, platelet-derived growth factor, colony stimulating factor-1, and the cytokines leukemia inhibitory factor and oncostatin M. The growth factors also activated a third, distinct but related, DNA-binding protein in addition to APRF and p91. This novel factor or a closely related one, but neither APRF nor p91, was also activated in lymphoid cells by interleukin-2, erythropoietin, and interleukin-3. Activation of APRF, p91, and additional members of the ISGF3 family is thus a general feature of a wide variety of signaling pathways, integrating diverse signals through common transcriptional regulators." @default.
• W1498102997 created "2016-06-24" @default.
• W1498102997 creator A5016812502 @default.
• W1498102997 creator A5068788861 @default.
• W1498102997 creator A5075435835 @default.
• W1498102997 date "1994-09-01" @default.
• W1498102997 modified "2023-10-16" @default.
• W1498102997 title "Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors." @default.
• W1498102997 cites W127609430 @default.
• W1498102997 cites W1521367633 @default.
• W1498102997 cites W1539475327 @default.
• W1498102997 cites W1965398762 @default.
• W1498102997 cites W1968177644 @default.
• W1498102997 cites W1968446194 @default.
• W1498102997 cites W1969979508 @default.
• W1498102997 cites W1972927903 @default.
• W1498102997 cites W1974607640 @default.
• W1498102997 cites W1974656027 @default.
• W1498102997 cites W1980632540 @default.
• W1498102997 cites W1981101169 @default.
• W1498102997 cites W1981799488 @default.
• W1498102997 cites W1983630074 @default.
• W1498102997 cites W1993243592 @default.
• W1498102997 cites W1996909138 @default.
• W1498102997 cites W1997935194 @default.
• W1498102997 cites W1999028040 @default.
• W1498102997 cites W2012438019 @default.
• W1498102997 cites W2030828553 @default.
• W1498102997 cites W2034974668 @default.
• W1498102997 cites W2038260402 @default.
• W1498102997 cites W2041187882 @default.
• W1498102997 cites W2043803403 @default.
• W1498102997 cites W2061241669 @default.
• W1498102997 cites W2062005942 @default.
• W1498102997 cites W2067626539 @default.
• W1498102997 cites W2067804511 @default.
• W1498102997 cites W2070242833 @default.
• W1498102997 cites W2074664341 @default.
• W1498102997 cites W2087709298 @default.
• W1498102997 cites W2094111001 @default.
• W1498102997 cites W2109389988 @default.
• W1498102997 cites W213732231 @default.
• W1498102997 cites W2398756024 @default.
• W1498102997 cites W318497777 @default.
• W1498102997 doi "https://doi.org/10.1016/s0021-9258(19)51096-1" @default.
• W1498102997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7523373" @default.
• W1498102997 hasPublicationYear "1994" @default.
• W1498102997 type Work @default.
• W1498102997 sameAs 1498102997 @default.
• W1498102997 citedByCount "148" @default.
• W1498102997 countsByYear W14981029972012 @default.
• W1498102997 countsByYear W14981029972013 @default.
• W1498102997 countsByYear W14981029972014 @default.
• W1498102997 countsByYear W14981029972015 @default.
• W1498102997 countsByYear W14981029972016 @default.
• W1498102997 countsByYear W14981029972017 @default.
• W1498102997 countsByYear W14981029972018 @default.
• W1498102997 countsByYear W14981029972019 @default.
• W1498102997 countsByYear W14981029972020 @default.
• W1498102997 countsByYear W14981029972021 @default.
• W1498102997 countsByYear W14981029972023 @default.
• W1498102997 crossrefType "journal-article" @default.
• W1498102997 hasAuthorship W1498102997A5016812502 @default.
• W1498102997 hasAuthorship W1498102997A5068788861 @default.
• W1498102997 hasAuthorship W1498102997A5075435835 @default.
• W1498102997 hasBestOaLocation W14981029971 @default.
• W1498102997 hasConcept C104317684 @default.
• W1498102997 hasConcept C170493617 @default.
• W1498102997 hasConcept C199360897 @default.
• W1498102997 hasConcept C203014093 @default.
• W1498102997 hasConcept C2775960820 @default.
• W1498102997 hasConcept C2776178377 @default.
• W1498102997 hasConcept C2781039887 @default.
• W1498102997 hasConcept C32300475 @default.
• W1498102997 hasConcept C41008148 @default.
• W1498102997 hasConcept C502942594 @default.
• W1498102997 hasConcept C54355233 @default.
• W1498102997 hasConcept C86339819 @default.
• W1498102997 hasConcept C86803240 @default.
• W1498102997 hasConcept C9173399 @default.
• W1498102997 hasConceptScore W1498102997C104317684 @default.
• W1498102997 hasConceptScore W1498102997C170493617 @default.
• W1498102997 hasConceptScore W1498102997C199360897 @default.
• W1498102997 hasConceptScore W1498102997C203014093 @default.
• W1498102997 hasConceptScore W1498102997C2775960820 @default.
• W1498102997 hasConceptScore W1498102997C2776178377 @default.
• W1498102997 hasConceptScore W1498102997C2781039887 @default.
• W1498102997 hasConceptScore W1498102997C32300475 @default.
• W1498102997 hasConceptScore W1498102997C41008148 @default.
• W1498102997 hasConceptScore W1498102997C502942594 @default.
• W1498102997 hasConceptScore W1498102997C54355233 @default.
• W1498102997 hasConceptScore W1498102997C86339819 @default.
• W1498102997 hasConceptScore W1498102997C86803240 @default.
• W1498102997 hasConceptScore W1498102997C9173399 @default.
• W1498102997 hasIssue "39" @default.
• W1498102997 hasLocation W14981029971 @default.
• W1498102997 hasOpenAccess W1498102997 @default.
• W1498102997 hasPrimaryLocation W14981029971 @default.

• next