Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498158052> ?p ?o ?g. }
- W1498158052 endingPage "2364" @default.
- W1498158052 startingPage "2352" @default.
- W1498158052 abstract "Chronic pain is a debilitating condition with unknown mechanism. Nociceptive sensitivity may be regulated by genetic factors, some of which have been separately linked to neuronal progenitor cells and neuronal differentiation. This suggests that genetic factors that interfere with neuronal differentiation may contribute to a chronic increase in nociceptive sensitivity, by extending the immature, hyperexcitable stage of spinal cord neurons. Although adult rodent spinal cord neurogenesis was previously demonstrated, the fate of these progenitor cells is unknown. Here, we show that peripheral nerve injury in adult rats induces extensive spinal cord neurogenesis and a long-term increase in the number of spinal cord laminae I-II neurons ipsilateral to injury. The production and maturation of these new neurons correlates with the time course and modulation of nociceptive behaviour, and transiently mimics the cellular and behavioural conditions present in genetically modified animal models of chronic pain. This suggests that the number of immature neurons present at any time in the spinal cord dorsal horns contributes to the regulation of nociceptive sensitivity. The continuous turnover of these neurons, which can fluctuate between normal and injured states, is a dynamic regulator of nociceptive sensitivity. In support of this hypothesis, we find that promoters of neuronal differentiation inhibit, while promoters of neurogenesis increase long-term nociception. TrkB agonists, well-known promoters of nociception in the short-term, significantly inhibit long-term nociception by promoting the differentiation of newly produced immature neurons. These findings suggest that promoters of neuronal differentiation may be used to alleviate chronic pain." @default.
- W1498158052 created "2016-06-24" @default.
- W1498158052 creator A5057140936 @default.
- W1498158052 creator A5081960363 @default.
- W1498158052 date "2015-07-30" @default.
- W1498158052 modified "2023-10-15" @default.
- W1498158052 title "Immature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity" @default.
- W1498158052 cites W117061413 @default.
- W1498158052 cites W1484682139 @default.
- W1498158052 cites W1530030261 @default.
- W1498158052 cites W1550122831 @default.
- W1498158052 cites W1567615855 @default.
- W1498158052 cites W1661938295 @default.
- W1498158052 cites W1814488946 @default.
- W1498158052 cites W1963940970 @default.
- W1498158052 cites W1965538993 @default.
- W1498158052 cites W1966997433 @default.
- W1498158052 cites W1969387231 @default.
- W1498158052 cites W1971063834 @default.
- W1498158052 cites W1976014326 @default.
- W1498158052 cites W1977211513 @default.
- W1498158052 cites W1977360479 @default.
- W1498158052 cites W1978269241 @default.
- W1498158052 cites W1978488532 @default.
- W1498158052 cites W1979675387 @default.
- W1498158052 cites W1980369017 @default.
- W1498158052 cites W1986662264 @default.
- W1498158052 cites W1987408946 @default.
- W1498158052 cites W1988816781 @default.
- W1498158052 cites W1996627744 @default.
- W1498158052 cites W2006733352 @default.
- W1498158052 cites W2009094782 @default.
- W1498158052 cites W2009387181 @default.
- W1498158052 cites W2018267283 @default.
- W1498158052 cites W2018734694 @default.
- W1498158052 cites W2028649176 @default.
- W1498158052 cites W2040010122 @default.
- W1498158052 cites W2040393174 @default.
- W1498158052 cites W2043655216 @default.
- W1498158052 cites W2046645100 @default.
- W1498158052 cites W2047925020 @default.
- W1498158052 cites W2050807666 @default.
- W1498158052 cites W2051875568 @default.
- W1498158052 cites W2052604373 @default.
- W1498158052 cites W2055541457 @default.
- W1498158052 cites W2056846496 @default.
- W1498158052 cites W2058020736 @default.
- W1498158052 cites W2060663619 @default.
- W1498158052 cites W2060943628 @default.
- W1498158052 cites W2061657649 @default.
- W1498158052 cites W2068856879 @default.
- W1498158052 cites W2070013811 @default.
- W1498158052 cites W2075715972 @default.
- W1498158052 cites W2076756254 @default.
- W1498158052 cites W2078828516 @default.
- W1498158052 cites W2081092833 @default.
- W1498158052 cites W2082306446 @default.
- W1498158052 cites W2089394861 @default.
- W1498158052 cites W2094354182 @default.
- W1498158052 cites W2095129531 @default.
- W1498158052 cites W2096867586 @default.
- W1498158052 cites W2103272211 @default.
- W1498158052 cites W2106654202 @default.
- W1498158052 cites W2111004700 @default.
- W1498158052 cites W2111343607 @default.
- W1498158052 cites W2112716968 @default.
- W1498158052 cites W2113138572 @default.
- W1498158052 cites W2117329255 @default.
- W1498158052 cites W2123048941 @default.
- W1498158052 cites W2124252984 @default.
- W1498158052 cites W2127070923 @default.
- W1498158052 cites W2127983299 @default.
- W1498158052 cites W2128475302 @default.
- W1498158052 cites W2137393689 @default.
- W1498158052 cites W2139208934 @default.
- W1498158052 cites W2139450672 @default.
- W1498158052 cites W2140441724 @default.
- W1498158052 cites W2144520896 @default.
- W1498158052 cites W2149242879 @default.
- W1498158052 cites W2154104720 @default.
- W1498158052 cites W2160205444 @default.
- W1498158052 cites W2160935383 @default.
- W1498158052 cites W2165867905 @default.
- W1498158052 cites W2170576851 @default.
- W1498158052 cites W2175495582 @default.
- W1498158052 cites W2320983896 @default.
- W1498158052 cites W2410935930 @default.
- W1498158052 doi "https://doi.org/10.1111/jcmm.12648" @default.
- W1498158052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4594677" @default.
- W1498158052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26223362" @default.
- W1498158052 hasPublicationYear "2015" @default.
- W1498158052 type Work @default.
- W1498158052 sameAs 1498158052 @default.
- W1498158052 citedByCount "12" @default.
- W1498158052 countsByYear W14981580522016 @default.
- W1498158052 countsByYear W14981580522017 @default.
- W1498158052 countsByYear W14981580522018 @default.
- W1498158052 countsByYear W14981580522019 @default.