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• W149816627 abstract "The effect of vitamins and other cofactors, or metabolites and anti-metabolites on the course of the experimental poliomyelitis infection, in vivo , have been extensively investigated. This chapter presents the data on this type of research. The animals kept on a vitamin B 1 -free diet were more resistant to infection than their controls. It seems that anorexia plays an aggravating role and similar effects have been achieved as, by low grade diets or insufficient general nourishment. On the other hand, phosphorus-, Ca-, and Vitamin D-deficiency increased the poliomyelitis morbidity. It was thought that amino-acid deficiency and especially, the lack of tryptophan might perhaps play an important part, in agreement with Anderson's findings on bacteriophage. The anti-metabolite and the idea of nutritional insufficiency caused by amino-acid deficiencies were tested in the studies of various workers, following the approach of Rasmussen and associates. Only p-aminophenylalanine seems to inhibit virus infection during the first week. Thus, the amino-acid administration increases, the antagonist decreases the incidence of the disease." @default.
• W149816627 created "2016-06-24" @default.
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• W149816627 date "1964-01-01" @default.
• W149816627 modified "2023-09-30" @default.
• W149816627 title "Biochemistry of Animal-adapted Poliomyelitis Infection in vivo" @default.
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• W149816627 doi "https://doi.org/10.1016/b978-0-08-010111-8.50010-2" @default.
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