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- W1498187761 abstract "Obesity is a complex metabolic disorder with a strong genetic component. There are many candidate genes for obesity and its related phenotypes. We studied genetic variations between Korean obese and lean groups. Polymorphisms investigated were the Msp I polymorphism of the α₂A-adrenergic receptor (α₂A-AR) gene, the Mnl I polymorphism of the α₂-adrenergic receptor (α₂-AR) gene, the BstO I polymorphism of the β₃-adrenergic receptor (β₃-AR) gene, the Pml I polymorphism of the lamin A/C (LMNA) gene, the Hga I polymorphism of the clearance receptor (NPRC) gene, the the Msp I polymorphism of the leptin gene, BclI polymorphism of the uncoupling protein 1 (UCP1) gene and the Hha I polymorphism of the fatty acid binding protein 2 (FABP2) gene. Among these genetic markers, Pml I polymorphism at the LMNA gene and Bcl I polymorphism at the UCP1 gene were significantly associated with obesity. However, further studies are required whether thease findings are reproduced in large population, although two polymorphisms might be useful as genetic markers in the ethiology of obesity in Korean population." @default.
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- W1498187761 date "2002-03-01" @default.
- W1498187761 modified "2023-09-23" @default.
- W1498187761 title "Genetic Variations of Eight Candidate Genes in Korean Obese Group" @default.
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