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• W1498261686 abstract "Cell wall composition of isogenic virulent-avirulent strain pairs of Histoplasma capsulatum varied markedly with respect to alpha-(1,3)-glucan content. When yeast cell walls were fractionated by standard techniques, the avirulent strains contained up to 1,000-fold less alpha-(1,3)-glucan than did their virulent parents. No alpha-(1,3)-glucan could be detected on the surface of the avirulent strain yeast cells if we used a mouse monoclonal antibody that recognized this polymer. A similar relationship between virulence and alpha-(1,3)-glucan has been described for Paracoccidioides brasiliensis. alpha-(1,3)-Glucan is also found in several other pathogenic fungi and may thus be an important common virulence determinant." @default.
• W1498261686 created "2016-06-24" @default.
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• W1498261686 date "1988-11-01" @default.
• W1498261686 modified "2023-09-23" @default.
• W1498261686 title "Cell walls from avirulent variants of Histoplasma capsulatum lack alpha-(1,3)-glucan" @default.
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• W1498261686 doi "https://doi.org/10.1128/iai.56.11.2997-3000.1988" @default.
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