FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498346306> ?p ?o ?g. }

• W1498346306 abstract "Primary cultures of estrogen-induced chick parenchymal liver cells have been used to study the assembly of the apolipoprotein and glycerolipid constituents of hepatic very low density lipoprotein (VLDL). Liver cell monolayers in serum-free medium were pulse-labeled for 2.5 min with either [3H]leucine or [3H]glycerol and were then chased for 4 h. The kinetics of secretion of VLDL 3H-apolipoproteins (labeled from [3H]leucine) and [3H]triacylglycerol and 3H-phosphoglycerides (labeled from [3H]glycerol) was determined through the chase. Maximal rates of VLDL [3H]triacylglycerol secretion were reached by 20-25 min into the chase, preceding the initial appearance of 3H-apolipoproteins in the medium at 30-35 min of chase time. The secretion of VLDL 3H-phosphoglycerides was maximal much earlier, between 5 and 15 min into the chase, plateaued for 15 min, and then began again at 30 min, thereby displaying a distinctive biphasic pattern. In the presence of cycloheximide or puromycin, such that apopeptide synthesis was halted from the start of the chase, the secretion of VLDL 3H-glycerolipid was depressed after 30 min of chase, without having influenced the temporal pattern of the newly synthesized VLDL 3H-apolipoprotein and 3H-glycerolipid secretion. As compared to the cycloheximide-treated cells in which apolipoprotein B nascent chains were arrested intracellularly, the puromycin-treated cells secreted discharged apolipoprotein B nascent chains as VLDL constituents assembled with triacylglycerol. The differential kinetics of 3H-apolipoprotein, [3H]triacylglycerol, and 3H-phosphoglyceride secretion as VLDL and the timing of the effects of protein synthesis inhibitors on their secretion indicate that VLDL constituents are assembled sequentially in the intact liver cell. Some VLDL phosphoglyceride and the VLDL triacylglycerol are assembled with apolipoprotein early in the secretory pathway, forming a triacylglycerol-rich lipid-protein particle into which further phosphoglyceride is introduced just prior to its secretion as mature VLDL." @default.
• W1498346306 created "2016-06-24" @default.
• W1498346306 creator A5012475457 @default.
• W1498346306 creator A5045369109 @default.
• W1498346306 date "1983-12-01" @default.
• W1498346306 modified "2023-09-30" @default.
• W1498346306 title "Sequential assembly of very low density lipoprotein apolipoproteins, triacylglycerol, and phosphoglycerides by the intact liver cell." @default.
• W1498346306 cites W1492377313 @default.
• W1498346306 cites W1526815729 @default.
• W1498346306 cites W1538584303 @default.
• W1498346306 cites W1545309548 @default.
• W1498346306 cites W1575864823 @default.
• W1498346306 cites W1938212460 @default.
• W1498346306 cites W1967037773 @default.
• W1498346306 cites W1967754583 @default.
• W1498346306 cites W1976424232 @default.
• W1498346306 cites W1984576656 @default.
• W1498346306 cites W1989534797 @default.
• W1498346306 cites W1995209400 @default.
• W1498346306 cites W2015152437 @default.
• W1498346306 cites W2028223025 @default.
• W1498346306 cites W2035520508 @default.
• W1498346306 cites W2046040890 @default.
• W1498346306 cites W2051090856 @default.
• W1498346306 cites W2052008556 @default.
• W1498346306 cites W2055589930 @default.
• W1498346306 cites W2061288821 @default.
• W1498346306 cites W2070814370 @default.
• W1498346306 cites W2105941016 @default.
• W1498346306 cites W2134016419 @default.
• W1498346306 cites W2152311269 @default.
• W1498346306 cites W2164162223 @default.
• W1498346306 cites W2164226796 @default.
• W1498346306 cites W2225803076 @default.
• W1498346306 cites W2309627888 @default.
• W1498346306 cites W4230065799 @default.
• W1498346306 cites W4246296632 @default.
• W1498346306 cites W77259799 @default.
• W1498346306 cites W98753134 @default.
• W1498346306 doi "https://doi.org/10.1016/s0021-9258(17)43890-7" @default.
• W1498346306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6643499" @default.
• W1498346306 hasPublicationYear "1983" @default.
• W1498346306 type Work @default.
• W1498346306 sameAs 1498346306 @default.
• W1498346306 citedByCount "73" @default.
• W1498346306 countsByYear W14983463062020 @default.
• W1498346306 crossrefType "journal-article" @default.
• W1498346306 hasAuthorship W1498346306A5012475457 @default.
• W1498346306 hasAuthorship W1498346306A5045369109 @default.
• W1498346306 hasBestOaLocation W14983463061 @default.
• W1498346306 hasConcept C126322002 @default.
• W1498346306 hasConcept C2776580952 @default.
• W1498346306 hasConcept C2778128677 @default.
• W1498346306 hasConcept C2778163477 @default.
• W1498346306 hasConcept C2779134260 @default.
• W1498346306 hasConcept C2779200571 @default.
• W1498346306 hasConcept C2780072125 @default.
• W1498346306 hasConcept C3675279 @default.
• W1498346306 hasConcept C49039625 @default.
• W1498346306 hasConcept C515207424 @default.
• W1498346306 hasConcept C55493867 @default.
• W1498346306 hasConcept C57089818 @default.
• W1498346306 hasConcept C62746215 @default.
• W1498346306 hasConcept C71924100 @default.
• W1498346306 hasConcept C8243546 @default.
• W1498346306 hasConcept C86803240 @default.
• W1498346306 hasConceptScore W1498346306C126322002 @default.
• W1498346306 hasConceptScore W1498346306C2776580952 @default.
• W1498346306 hasConceptScore W1498346306C2778128677 @default.
• W1498346306 hasConceptScore W1498346306C2778163477 @default.
• W1498346306 hasConceptScore W1498346306C2779134260 @default.
• W1498346306 hasConceptScore W1498346306C2779200571 @default.
• W1498346306 hasConceptScore W1498346306C2780072125 @default.
• W1498346306 hasConceptScore W1498346306C3675279 @default.
• W1498346306 hasConceptScore W1498346306C49039625 @default.
• W1498346306 hasConceptScore W1498346306C515207424 @default.
• W1498346306 hasConceptScore W1498346306C55493867 @default.
• W1498346306 hasConceptScore W1498346306C57089818 @default.
• W1498346306 hasConceptScore W1498346306C62746215 @default.
• W1498346306 hasConceptScore W1498346306C71924100 @default.
• W1498346306 hasConceptScore W1498346306C8243546 @default.
• W1498346306 hasConceptScore W1498346306C86803240 @default.
• W1498346306 hasLocation W14983463061 @default.
• W1498346306 hasOpenAccess W1498346306 @default.
• W1498346306 hasPrimaryLocation W14983463061 @default.
• W1498346306 hasRelatedWork W1486424025 @default.
• W1498346306 hasRelatedWork W1489766749 @default.
• W1498346306 hasRelatedWork W1492377313 @default.
• W1498346306 hasRelatedWork W1526815729 @default.
• W1498346306 hasRelatedWork W1557907146 @default.
• W1498346306 hasRelatedWork W1565474821 @default.
• W1498346306 hasRelatedWork W1586986973 @default.
• W1498346306 hasRelatedWork W168008062 @default.
• W1498346306 hasRelatedWork W1775749144 @default.
• W1498346306 hasRelatedWork W1921601722 @default.
• W1498346306 hasRelatedWork W1956183677 @default.
• W1498346306 hasRelatedWork W2011347863 @default.
• W1498346306 hasRelatedWork W2016092362 @default.
• W1498346306 hasRelatedWork W2027270726 @default.
• W1498346306 hasRelatedWork W2052008556 @default.

• next