Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498465913> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1498465913 endingPage "21" @default.
- W1498465913 startingPage "1317" @default.
- W1498465913 abstract "Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, substantial levels of binding (80 fmol/microgram DNA) were observed in liver by 1 day, and maximum steady-state values averaging 230 fmol/microgram DNA were reached by 30 days. Initially, during the continuous feeding, about 80% of the total C-8 adducts were deacetylated [N-deoxyguanosin(8-yl)aminofluorene], and this proportion increased to about 97% by 15 and 30 days of administration of 0.04 and 0.02% 2-acetylaminofluorene diets, respectively. Levels of C-8 adducts bound to kidney DNA in the same animals averaged 10 to 15% of the liver values with greater than or equal to 80% of these adducts in the deacetylated form. In separate experiments, rats were exposed to 2-acetylaminofluorene for 3, 7, 28, and 112 days; the carcinogen-containing diet was discontinued; and C-8 adducts were monitored during 1, 7, and 28 days of feeding control diet. At both carcinogen doses, after dietary administration for 3 or 7 days, there was a rapid decrease in liver C-8 adducts so that, after 28 days on control diet, 65 to 90% of the original adducts were no longer present in the DNA. In contrast, in animals fed 0.02% 2-acetylaminofluorene for 28 days, there were high levels (70 to 100% of the original C-8 adduct) remaining on the DNA at the end of 28 days on control diet. This apparent loss in capacity for removal of C-8 adducts is discussed in relation to biological and biochemical changes induced in the rat liver during 2-acetylaminofluorene hepatocarcinogens." @default.
- W1498465913 created "2016-06-24" @default.
- W1498465913 creator A5000983053 @default.
- W1498465913 creator A5025822048 @default.
- W1498465913 creator A5039601554 @default.
- W1498465913 date "1982-04-01" @default.
- W1498465913 modified "2023-09-23" @default.
- W1498465913 title "Formation and removal of (guan-8-yl)-DNA-2-acetylaminofluorene adducts in liver and kidney of male rats given dietary 2-acetylaminofluorene." @default.
- W1498465913 cites W1558031393 @default.
- W1498465913 cites W1562777547 @default.
- W1498465913 cites W1594216266 @default.
- W1498465913 cites W1605499907 @default.
- W1498465913 cites W1618967907 @default.
- W1498465913 cites W1860461830 @default.
- W1498465913 cites W1977145576 @default.
- W1498465913 cites W2039641512 @default.
- W1498465913 cites W2040676271 @default.
- W1498465913 cites W2041037355 @default.
- W1498465913 cites W2106250616 @default.
- W1498465913 cites W2116974204 @default.
- W1498465913 cites W2127075965 @default.
- W1498465913 cites W2129694214 @default.
- W1498465913 cites W2133909382 @default.
- W1498465913 cites W2149602703 @default.
- W1498465913 cites W2153787728 @default.
- W1498465913 cites W2291956401 @default.
- W1498465913 cites W2298548186 @default.
- W1498465913 cites W2395297185 @default.
- W1498465913 cites W2138408021 @default.
- W1498465913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7060010" @default.
- W1498465913 hasPublicationYear "1982" @default.
- W1498465913 type Work @default.
- W1498465913 sameAs 1498465913 @default.
- W1498465913 citedByCount "22" @default.
- W1498465913 countsByYear W14984659132016 @default.
- W1498465913 crossrefType "journal-article" @default.
- W1498465913 hasAuthorship W1498465913A5000983053 @default.
- W1498465913 hasAuthorship W1498465913A5025822048 @default.
- W1498465913 hasAuthorship W1498465913A5039601554 @default.
- W1498465913 hasConcept C108204754 @default.
- W1498465913 hasConcept C114246631 @default.
- W1498465913 hasConcept C116073593 @default.
- W1498465913 hasConcept C126322002 @default.
- W1498465913 hasConcept C134018914 @default.
- W1498465913 hasConcept C178790620 @default.
- W1498465913 hasConcept C181199279 @default.
- W1498465913 hasConcept C185592680 @default.
- W1498465913 hasConcept C202751555 @default.
- W1498465913 hasConcept C2779107934 @default.
- W1498465913 hasConcept C2779838395 @default.
- W1498465913 hasConcept C2780091579 @default.
- W1498465913 hasConcept C2780441211 @default.
- W1498465913 hasConcept C51296783 @default.
- W1498465913 hasConcept C552990157 @default.
- W1498465913 hasConcept C55493867 @default.
- W1498465913 hasConcept C71924100 @default.
- W1498465913 hasConcept C86803240 @default.
- W1498465913 hasConcept C87644729 @default.
- W1498465913 hasConceptScore W1498465913C108204754 @default.
- W1498465913 hasConceptScore W1498465913C114246631 @default.
- W1498465913 hasConceptScore W1498465913C116073593 @default.
- W1498465913 hasConceptScore W1498465913C126322002 @default.
- W1498465913 hasConceptScore W1498465913C134018914 @default.
- W1498465913 hasConceptScore W1498465913C178790620 @default.
- W1498465913 hasConceptScore W1498465913C181199279 @default.
- W1498465913 hasConceptScore W1498465913C185592680 @default.
- W1498465913 hasConceptScore W1498465913C202751555 @default.
- W1498465913 hasConceptScore W1498465913C2779107934 @default.
- W1498465913 hasConceptScore W1498465913C2779838395 @default.
- W1498465913 hasConceptScore W1498465913C2780091579 @default.
- W1498465913 hasConceptScore W1498465913C2780441211 @default.
- W1498465913 hasConceptScore W1498465913C51296783 @default.
- W1498465913 hasConceptScore W1498465913C552990157 @default.
- W1498465913 hasConceptScore W1498465913C55493867 @default.
- W1498465913 hasConceptScore W1498465913C71924100 @default.
- W1498465913 hasConceptScore W1498465913C86803240 @default.
- W1498465913 hasConceptScore W1498465913C87644729 @default.
- W1498465913 hasIssue "4" @default.
- W1498465913 hasLocation W14984659131 @default.
- W1498465913 hasOpenAccess W1498465913 @default.
- W1498465913 hasPrimaryLocation W14984659131 @default.
- W1498465913 hasRelatedWork W1498465913 @default.
- W1498465913 hasRelatedWork W1977145576 @default.
- W1498465913 hasRelatedWork W1996893063 @default.
- W1498465913 hasRelatedWork W2033907669 @default.
- W1498465913 hasRelatedWork W204914110 @default.
- W1498465913 hasRelatedWork W2051213863 @default.
- W1498465913 hasRelatedWork W2073957380 @default.
- W1498465913 hasRelatedWork W2083309301 @default.
- W1498465913 hasRelatedWork W2147552574 @default.
- W1498465913 hasRelatedWork W2149602703 @default.
- W1498465913 hasVolume "42" @default.
- W1498465913 isParatext "false" @default.
- W1498465913 isRetracted "false" @default.
- W1498465913 magId "1498465913" @default.
- W1498465913 workType "article" @default.