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- W1498475304 endingPage "257" @default.
- W1498475304 startingPage "244" @default.
- W1498475304 abstract "Therapeutic hypothermia has emerged as a remarkably effective method of neuroprotection from ischemia and is being increasingly used in clinics. Accordingly, it is also a subject of considerable attention from a basic scientific research perspective. One of the fundamental problems, with which current studies are concerned, is the optimal method of inducing hypothermia. This review seeks to provide a broad theoretical framework for approaching this problem, and to discuss how a novel promising strategy of pharmacological modulation of the thermosensitive ion channels fits into this framework. Various physical, anatomical, physiological and molecular aspects of thermoregulation, which provide the foundation for this text, have been comprehensively reviewed and will not be discussed exhaustively here. Instead, the first part of the current review, which may be helpful for a broader readership outside of thermoregulation research, will build on this existing knowledge to outline possible opportunities and research directions aimed at controlling body temperature. The second part, aimed at a more specialist audience, will highlight the conceptual advantages and practical limitations of novel molecular agents targeting thermosensitive Transient Receptor Potential (TRP) channels in achieving this goal. Two particularly promising members of this channel family, namely TRP melastatin 8 (TRPM8) and TRP vanilloid 1 (TRPV1), will be discussed in greater detail." @default.
- W1498475304 created "2016-06-24" @default.
- W1498475304 creator A5046544080 @default.
- W1498475304 creator A5051283321 @default.
- W1498475304 date "2015-04-27" @default.
- W1498475304 modified "2023-10-15" @default.
- W1498475304 title "Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations" @default.
- W1498475304 cites W1493084931 @default.
- W1498475304 cites W1503600085 @default.
- W1498475304 cites W1511198581 @default.
- W1498475304 cites W1573141201 @default.
- W1498475304 cites W1939684121 @default.
- W1498475304 cites W1954902754 @default.
- W1498475304 cites W1964254852 @default.
- W1498475304 cites W1968817279 @default.
- W1498475304 cites W1969332945 @default.
- W1498475304 cites W1974814120 @default.
- W1498475304 cites W1975332997 @default.
- W1498475304 cites W1981828112 @default.
- W1498475304 cites W1984958389 @default.
- W1498475304 cites W1985474963 @default.
- W1498475304 cites W1989442972 @default.
- W1498475304 cites W1992839998 @default.
- W1498475304 cites W1994367077 @default.
- W1498475304 cites W1995301708 @default.
- W1498475304 cites W1995330222 @default.
- W1498475304 cites W1995361060 @default.
- W1498475304 cites W1999370442 @default.
- W1498475304 cites W2001114069 @default.
- W1498475304 cites W2001401352 @default.
- W1498475304 cites W2001789338 @default.
- W1498475304 cites W2003880002 @default.
- W1498475304 cites W2009880851 @default.
- W1498475304 cites W2011024719 @default.
- W1498475304 cites W2014738430 @default.
- W1498475304 cites W2019989846 @default.
- W1498475304 cites W2021006519 @default.
- W1498475304 cites W2022419105 @default.
- W1498475304 cites W2028438640 @default.
- W1498475304 cites W2032462838 @default.
- W1498475304 cites W2033620602 @default.
- W1498475304 cites W2039217013 @default.
- W1498475304 cites W2039381345 @default.
- W1498475304 cites W2039605663 @default.
- W1498475304 cites W2039979982 @default.
- W1498475304 cites W2041265697 @default.
- W1498475304 cites W2047896416 @default.
- W1498475304 cites W2050749485 @default.
- W1498475304 cites W2052377203 @default.
- W1498475304 cites W2056639454 @default.
- W1498475304 cites W2059759502 @default.
- W1498475304 cites W2062642814 @default.
- W1498475304 cites W2065840181 @default.
- W1498475304 cites W2067433745 @default.
- W1498475304 cites W2072890489 @default.
- W1498475304 cites W2076503188 @default.
- W1498475304 cites W2079334829 @default.
- W1498475304 cites W2080595188 @default.
- W1498475304 cites W2082788583 @default.
- W1498475304 cites W2086279846 @default.
- W1498475304 cites W2087665027 @default.
- W1498475304 cites W2092072642 @default.
- W1498475304 cites W2092166214 @default.
- W1498475304 cites W2092774759 @default.
- W1498475304 cites W2094549307 @default.
- W1498475304 cites W2094565333 @default.
- W1498475304 cites W2098951649 @default.
- W1498475304 cites W2099414466 @default.
- W1498475304 cites W2102088757 @default.
- W1498475304 cites W2104869294 @default.
- W1498475304 cites W2105155111 @default.
- W1498475304 cites W2105660997 @default.
- W1498475304 cites W2106207830 @default.
- W1498475304 cites W2106682644 @default.
- W1498475304 cites W2107057154 @default.
- W1498475304 cites W2107705149 @default.
- W1498475304 cites W2112164385 @default.
- W1498475304 cites W2112763282 @default.
- W1498475304 cites W2115250852 @default.
- W1498475304 cites W2117173889 @default.
- W1498475304 cites W2119257675 @default.
- W1498475304 cites W2119934340 @default.
- W1498475304 cites W2120229762 @default.
- W1498475304 cites W2123289930 @default.
- W1498475304 cites W2123673561 @default.
- W1498475304 cites W2126229620 @default.
- W1498475304 cites W2127653983 @default.
- W1498475304 cites W2130143178 @default.
- W1498475304 cites W2131238198 @default.
- W1498475304 cites W2135687416 @default.
- W1498475304 cites W2136344623 @default.
- W1498475304 cites W2137234744 @default.
- W1498475304 cites W2138376387 @default.
- W1498475304 cites W2144025192 @default.
- W1498475304 cites W2145427448 @default.
- W1498475304 cites W2146086408 @default.
- W1498475304 cites W2147128496 @default.
- W1498475304 cites W2148418576 @default.