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- W1498485796 abstract "Neurotrophic factors are endogenous proteins that modulate cell-signaling pathways regulating stem cell proliferation, neuronal differentiation, differentiation, growth, and regeneration. They are generally small, soluble proteins with molecular weights between 13 and 24 kDa and often function as homodimers. This chapter reviews neurotrophic factors for midbrain dopamine neurons, the principal neuronal population affected in the pathogenesis of Parkinson's disease (PD). Like most signaling molecules, neurotrophic factors can be divided into families of closely related molecules. They are produced by both glial cells and neurons. Trophic factor interactions with receptors can be complex. Many neurotrophic factors are both neuroprotective (protect neurons from injury) and neurorestorative (promote structural and functional regeneration). During development, excessive numbers of neurons are generated in many brain regions. Developing neurons that fail to make connections with appropriate trophic factor-producing target cells die from being deprived of necessary neurotrophic factors." @default.
- W1498485796 created "2016-06-24" @default.
- W1498485796 creator A5037458498 @default.
- W1498485796 creator A5037708891 @default.
- W1498485796 creator A5048761265 @default.
- W1498485796 date "2007-01-01" @default.
- W1498485796 modified "2023-10-18" @default.
- W1498485796 title "Neurotrophic factors and Parkinson's disease" @default.
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