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- W1498500684 abstract "Summary: To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction /sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1 * 0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46 % vs 3.45 %, P＜0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors." @default.
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- W1498500684 date "2002-01-01" @default.
- W1498500684 modified "2023-09-24" @default.
- W1498500684 title "Possible Association of HLA—DRB1 Gene with the Autoantibody against Myocardial Mitochondria ADP／ATP Carrier in Dilated Cardiomyopathy" @default.
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