FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498558807> ?p ?o ?g. }

• W1498558807 endingPage "9030" @default.
• W1498558807 startingPage "9018" @default.
• W1498558807 abstract "Breast cancer is classified into different subtypes that are associated with different patient survival outcomes, underscoring the importance of understanding the role of precursor cell and genetic alterations in determining tumor subtypes. In this study, we evaluated the oncogenic phenotype of two distinct mammary stem/progenitor cell types designated as K5+/K19- or K5+/K19+ upon introduction of identical combinations of oncogenes-mutant H-Ras (mRas) and mutant p53 (mp53), together with either wild-type ErbB2(wtErbB2) or wild-type EGFR (wtEGFR). We examined their tumor forming and metastasis potential, using both in-vitro and in-vivo assays. Both the combinations efficiently transformed K5+/K19- or K5+/K19+ cells. Xenograft tumors formed by these cells were histologically heterogeneous, with variable proportions of luminal, basal-like and claudin-low type components depending on the cell types and oncogene combinations. Notably, K5+/K19- cells transformed with mRas/mp53/wtEGFR combination had a significantly longer latency for primary tumor development than other cell lines but more lung metastasis incidence than same cells expressing mRas/mp53/wtErbB2. K5+/K19+ cells exhibit shorter overall tumor latency, and high metastatic potential than K5+/K19- cells, suggesting that these K19+ progenitors are more susceptible to oncogenesis and metastasis. Our results suggest that both genetic alterations and cell type of origin contribute to oncogenic phenotype of breast tumors." @default.
• W1498558807 created "2016-06-24" @default.
• W1498558807 creator A5001446897 @default.
• W1498558807 creator A5009870959 @default.
• W1498558807 creator A5038181633 @default.
• W1498558807 creator A5085762574 @default.
• W1498558807 creator A5088112834 @default.
• W1498558807 date "2015-03-02" @default.
• W1498558807 modified "2023-09-23" @default.
• W1498558807 title "Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes" @default.
• W1498558807 cites W1951978965 @default.
• W1498558807 cites W1974784117 @default.
• W1498558807 cites W1979946545 @default.
• W1498558807 cites W1981672008 @default.
• W1498558807 cites W1999027637 @default.
• W1498558807 cites W2007916146 @default.
• W1498558807 cites W2010344294 @default.
• W1498558807 cites W2014464681 @default.
• W1498558807 cites W2014691022 @default.
• W1498558807 cites W2023427658 @default.
• W1498558807 cites W2027345413 @default.
• W1498558807 cites W2041263494 @default.
• W1498558807 cites W2041783360 @default.
• W1498558807 cites W2043409879 @default.
• W1498558807 cites W2044702943 @default.
• W1498558807 cites W2057697080 @default.
• W1498558807 cites W2059048157 @default.
• W1498558807 cites W2060980627 @default.
• W1498558807 cites W2072923149 @default.
• W1498558807 cites W2073336166 @default.
• W1498558807 cites W2082887122 @default.
• W1498558807 cites W2085659118 @default.
• W1498558807 cites W2086668163 @default.
• W1498558807 cites W2096283457 @default.
• W1498558807 cites W2096867589 @default.
• W1498558807 cites W2097255042 @default.
• W1498558807 cites W2098915144 @default.
• W1498558807 cites W2102085111 @default.
• W1498558807 cites W2105767082 @default.
• W1498558807 cites W2106195342 @default.
• W1498558807 cites W2106292881 @default.
• W1498558807 cites W2121672045 @default.
• W1498558807 cites W2122003447 @default.
• W1498558807 cites W2124272324 @default.
• W1498558807 cites W2127617517 @default.
• W1498558807 cites W2131994307 @default.
• W1498558807 cites W2135077494 @default.
• W1498558807 cites W2138369573 @default.
• W1498558807 cites W2140152239 @default.
• W1498558807 cites W2141393790 @default.
• W1498558807 cites W2146771808 @default.
• W1498558807 cites W2152835558 @default.
• W1498558807 cites W2153051750 @default.
• W1498558807 cites W2163890392 @default.
• W1498558807 cites W2169961966 @default.
• W1498558807 cites W2219978888 @default.
• W1498558807 cites W2259802687 @default.
• W1498558807 cites W2331056746 @default.
• W1498558807 cites W2394654621 @default.
• W1498558807 cites W2560367415 @default.
• W1498558807 doi "https://doi.org/10.18632/oncotarget.3379" @default.
• W1498558807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4496199" @default.
• W1498558807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25940703" @default.
• W1498558807 hasPublicationYear "2015" @default.
• W1498558807 type Work @default.
• W1498558807 sameAs 1498558807 @default.
• W1498558807 citedByCount "19" @default.
• W1498558807 countsByYear W14985588072015 @default.
• W1498558807 countsByYear W14985588072016 @default.
• W1498558807 countsByYear W14985588072017 @default.
• W1498558807 countsByYear W14985588072018 @default.
• W1498558807 countsByYear W14985588072019 @default.
• W1498558807 countsByYear W14985588072020 @default.
• W1498558807 countsByYear W14985588072021 @default.
• W1498558807 countsByYear W14985588072022 @default.
• W1498558807 countsByYear W14985588072023 @default.
• W1498558807 crossrefType "journal-article" @default.
• W1498558807 hasAuthorship W1498558807A5001446897 @default.
• W1498558807 hasAuthorship W1498558807A5009870959 @default.
• W1498558807 hasAuthorship W1498558807A5038181633 @default.
• W1498558807 hasAuthorship W1498558807A5085762574 @default.
• W1498558807 hasAuthorship W1498558807A5088112834 @default.
• W1498558807 hasBestOaLocation W14985588071 @default.
• W1498558807 hasConcept C104317684 @default.
• W1498558807 hasConcept C121608353 @default.
• W1498558807 hasConcept C127716648 @default.
• W1498558807 hasConcept C1491633281 @default.
• W1498558807 hasConcept C189014844 @default.
• W1498558807 hasConcept C201750760 @default.
• W1498558807 hasConcept C2779013556 @default.
• W1498558807 hasConcept C28328180 @default.
• W1498558807 hasConcept C502942594 @default.
• W1498558807 hasConcept C54355233 @default.
• W1498558807 hasConcept C555283112 @default.
• W1498558807 hasConcept C81885089 @default.
• W1498558807 hasConcept C86803240 @default.
• W1498558807 hasConcept C95444343 @default.
• W1498558807 hasConceptScore W1498558807C104317684 @default.

• next