FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1498589050> ?p ?o ?g. }

• W1498589050 abstract "of a dissertation at the University of Miami. Dissertation supervised by Professor David J. Lee No. of pages in text. (126) Background: Dilated Cardiomyopathy (DCM) is the most common functional type of cardiomyopathy in children with significant morbidity and the leading indication for cardiac transplant over 5 years of age. Identification of baseline risk factors for failing medical management by etiologic grouping remain to be elucidated in a large populationbased study. The competing risk for heart death between all-cause mortality and heart transplantation is often overestimated in the literature and may obscure additional novel risk factors associated with poor clinical outcomes. Methods: The National Heart Lung and Blood Institute Pediatric Cardiomyopathy Registry collected longitudinal data from 1731 children with DCM in North America from 1990 to 2007. Composite endpoint (CEP) was the earlier occurrence of death or heart transplant. Univariate and multivariate predictors were identified from demographic and echocardiographic data (expressed as z-scores) collected within 30 days of diagnosis. A competing risk analysis was performed calculating cumulative incidence and identifying novel prognostic factors. All analyses were performed by etiologic group. Results: Multivariate Cox regression identified the highest mortality risk among children with idiopathic disease (N=1192, CEP: 41%) when diagnosed over age 6 years, and with congestive heart failure (CHF) and decreased left ventricular fractional shortening (FS). Risk factors for those with myocarditis (N=272, CEP: 26%) were older age, CHF, and increased left ventricular (LV) end-diastolic dimension (EDD); while for neuromuscular disease (N=139, CEP: 40%), it was a decreased FS and increased EDD. Only univariate predictors were identified for children with familial isolated cardiomyopathy (N=79, CEP: 44%) including: CHF, increased EDD, end-systolic dimension, or LV mass, and decreased FS or ejection fraction), while for children with inborn errors of metabolism (N=43, CEP: 33%) risk factors included: a positive family history of cardiomyopathy or genetic syndromes. The group of children with malformation syndromes (N=6, CEP: 50%) was not large enough to model. Comparison of cause-specific event rates between Kaplan-Meier and cumulative incidence demonstrated an overestimation with the former method. Competing risk multivariate regression showed similar models to those for CEP, with the following exceptions: for neuromuscular disease, an increased EDD had a larger hazard ratio for transplant than for death; for idiopathic disease, an increased EDD was associated with transplant, but not with death, and growth retardation (height-for-age zscore) was associated with death but not transplant. Conclusions: Within etiologic grouping, demographics and echocardiographic values at diagnosis have varying predictive value. Generally, the presence of symptomatic disease in the form of CHF, echocardiographic evidence of more severe DCM, and increased age were indicative of worse outcomes. These results help to validate those from conflicting studies; however, they suggest that etiology modifies the importance of particular factors. Analysis of competing risk provides an alternate interpretation of studies with composite endpoints and assists in the transfer of clinically relevant information. For children with idiopathic and neuromuscular disease, the degree of dilation had a differential effect that has gone unrecognized. The novel finding of reduced stature and its effect on mortality suggests a potential for treatment and mitigation of poor outcomes in idiopathic DCM. Both increased dilation and reduced stature could be used to improve the triage process and refer children to cardiac transplantation who otherwise might die prematurely and unnecessarily. Subsequent studies on the utility of these factors and their effect on improving survival are warranted." @default.
• W1498589050 created "2016-06-24" @default.
• W1498589050 creator A5025612595 @default.
• W1498589050 date "2009-01-01" @default.
• W1498589050 modified "2023-09-24" @default.
• W1498589050 title "Pediatric dilated cardiomyopathy: Baseline predictors of outcomes in the Pediatric Cardiomyopathy Registry" @default.
• W1498589050 cites W1522207865 @default.
• W1498589050 cites W1575944700 @default.
• W1498589050 cites W1817767767 @default.
• W1498589050 cites W1966620981 @default.
• W1498589050 cites W1971025398 @default.
• W1498589050 cites W1974001229 @default.
• W1498589050 cites W1974145389 @default.
• W1498589050 cites W1974383169 @default.
• W1498589050 cites W1976606692 @default.
• W1498589050 cites W1976796709 @default.
• W1498589050 cites W1977127536 @default.
• W1498589050 cites W1986167000 @default.
• W1498589050 cites W1986638371 @default.
• W1498589050 cites W1991332142 @default.
• W1498589050 cites W1992459970 @default.
• W1498589050 cites W1996110848 @default.
• W1498589050 cites W1996122438 @default.
• W1498589050 cites W1997588202 @default.
• W1498589050 cites W2002208962 @default.
• W1498589050 cites W2005759906 @default.
• W1498589050 cites W2006555760 @default.
• W1498589050 cites W2007925038 @default.
• W1498589050 cites W2009876051 @default.
• W1498589050 cites W2010790997 @default.
• W1498589050 cites W2010792302 @default.
• W1498589050 cites W2014047274 @default.
• W1498589050 cites W2016342422 @default.
• W1498589050 cites W2018727646 @default.
• W1498589050 cites W2021019744 @default.
• W1498589050 cites W2025048874 @default.
• W1498589050 cites W2028241603 @default.
• W1498589050 cites W2033072021 @default.
• W1498589050 cites W2034050166 @default.
• W1498589050 cites W2038981426 @default.
• W1498589050 cites W2040081997 @default.
• W1498589050 cites W2041982853 @default.
• W1498589050 cites W2043985983 @default.
• W1498589050 cites W2050818720 @default.
• W1498589050 cites W2052107498 @default.
• W1498589050 cites W2060040514 @default.
• W1498589050 cites W2060797952 @default.
• W1498589050 cites W2066317263 @default.
• W1498589050 cites W2066542332 @default.
• W1498589050 cites W2070709304 @default.
• W1498589050 cites W2070794434 @default.
• W1498589050 cites W2075792713 @default.
• W1498589050 cites W2078416451 @default.
• W1498589050 cites W2080774746 @default.
• W1498589050 cites W2082700292 @default.
• W1498589050 cites W2089205904 @default.
• W1498589050 cites W2090537494 @default.
• W1498589050 cites W2091960642 @default.
• W1498589050 cites W2092032062 @default.
• W1498589050 cites W2092135214 @default.
• W1498589050 cites W2101271603 @default.
• W1498589050 cites W2105930355 @default.
• W1498589050 cites W2109452637 @default.
• W1498589050 cites W2110115921 @default.
• W1498589050 cites W2117742026 @default.
• W1498589050 cites W2119770786 @default.
• W1498589050 cites W2123286156 @default.
• W1498589050 cites W2123801190 @default.
• W1498589050 cites W2125052019 @default.
• W1498589050 cites W2127385713 @default.
• W1498589050 cites W2129404797 @default.
• W1498589050 cites W2135259647 @default.
• W1498589050 cites W2139537565 @default.
• W1498589050 cites W2144059284 @default.
• W1498589050 cites W2144336397 @default.
• W1498589050 cites W2156200001 @default.
• W1498589050 cites W2157552969 @default.
• W1498589050 cites W2157807142 @default.
• W1498589050 cites W2160819972 @default.
• W1498589050 cites W2163715968 @default.
• W1498589050 cites W2167356620 @default.
• W1498589050 cites W2167363119 @default.
• W1498589050 cites W2187232826 @default.
• W1498589050 cites W2280623516 @default.
• W1498589050 cites W2394978494 @default.
• W1498589050 cites W2398631513 @default.
• W1498589050 cites W2414134516 @default.
• W1498589050 cites W2421735718 @default.
• W1498589050 cites W2465739274 @default.
• W1498589050 cites W2521080673 @default.
• W1498589050 cites W2748005541 @default.
• W1498589050 cites W3205848469 @default.
• W1498589050 cites W56970078 @default.
• W1498589050 cites W3146849155 @default.
• W1498589050 hasPublicationYear "2009" @default.
• W1498589050 type Work @default.
• W1498589050 sameAs 1498589050 @default.
• W1498589050 citedByCount "0" @default.
• W1498589050 crossrefType "journal-article" @default.
• W1498589050 hasAuthorship W1498589050A5025612595 @default.

• next