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• W1498746651 abstract "To evaluate the association between chronic opioid use for non-cancer pain and fracture risk by conducting a meta-analysis of cohort studies.Cohort studies were identified by searching PubMed and EMBASE from their inception to July 2014. A fracture was considered an endpoint. The information was extracted by two authors independently. When the heterogeneity was significant, a random-effects model was used to calculate the overall pooled risk estimates.Eight cohort studies were included in the final meta-analysis. On the basis of the Newcastle-Ottawa Scale (NOS), six studies were considered to be of high quality. The overall combined relative risk for the use of opioids and fractures was 1.88 (95% confidence interval [CI] 1.51-2.34). A subgroup analysis revealed the sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed.This meta-analysis of cohort studies demonstrates that opioids significantly increase the risk of fractures." @default.
• W1498746651 created "2016-06-24" @default.
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• W1498746651 date "2015-06-01" @default.
• W1498746651 modified "2023-10-02" @default.
• W1498746651 title "Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies" @default.
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• W1498746651 doi "https://doi.org/10.1371/journal.pone.0128232" @default.
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